Ionic liquid supported 4-HO-Pro-Val derived organocatalysts for asymmetric aldol reactions in the presence of water

被引：20

作者：

Kucherenko, Alexander S. ^{[1
]}

Perepelkin, Vasily V. ^{[1
]}

Zhdankina, Galina M. ^{[1
]}

Kryshtal, Galina V. ^{[1
]}

Srinivasan, Easwar ^{[2
]}

Inani, Heena ^{[2
]}

Zlotin, Sergei G. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

[2] Cent Univ Rajasthan, Sch Chem Sci & Pharm, NH-8 Bandarsindri, Distt Ajmer, Rajasthan, India

来源：

MENDELEEV COMMUNICATIONS | 2016年 / 26卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

KINETIC RESOLUTION; PEPTIDE CATALYSTS; MICHAEL REACTIONS; CONTINUOUS-FLOW; EFFICIENT; PROLINE; NITROOLEFINS; 1,4-ADDITION; TRIPEPTIDES; DERIVATIVES;

D O I：

10.1016/j.mencom.2016.09.007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel (4R)-HO-(2S)-Pro-(S)-Val derivative tagged to 1-methyl-imidazolium cation and PF6- anion efficiently catalyzes asymmetric aldol reactions of cyclic ketones with aromatic aldehydes in aqueous environment to afford the corresponding aldols in high yield with moderate to high anti-diastereo- (dr up to 99 :1) and enantioselectivity (up to 98% ee). The catalyst was recycled 9 times in the same reaction without any decrease in selectivity values.

引用

页码：388 / 390

页数：3

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