Multifunctional drug delivery nanoparticles based on MIL-100 (Fe) for photoacoustic imaging-guided synergistic chemodynamic/chemo/photothermal breast cancer therapy

被引：29
作者：
Hu, Zhiming [1 ]
Xu, Caina [2 ]
Liang, Yonghao [1 ]
Liu, Taiyuan [1 ]
Tian, Huayu [3 ]
Zhang, Yingchao [1 ]
机构：
[1] Second Hosp Jilin Univ, Dept Breast Surg, Changchun 130041, Peoples R China
[2] Jilin Univ, Coll Basic Med Sci, Dept Biochem, Changchun 130021, Peoples R China
[3] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
来源：
MATERIALS & DESIGN | 2022年 / 223卷
基金：
中国国家自然科学基金;
关键词：
Photothermal therapy; Photoacoustic imaging; Chemodynamic therapy; Breast cancer; METAL-ORGANIC FRAMEWORKS; CARRIERS;
D O I：
10.1016/j.matdes.2022.111132
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Compared with visceral cancers, breast cancer is epidermal and can be efficiently eliminated by photoacoustic imaging (PAI)-guided cancer therapy. In this study, we developed multifunctional nanoparticles (DMTH NPs) by loading doxorubicin (DOX) into MIL-100, which were modified with tannic acid (TA) and hyaluronic acid (HA) using a simple and convenient method. MIL-100 (Fe) in DMTH NPs allowed for chemodynamic therapy by converting endogenous hydrogen peroxide (H2O2) into .OH through a Fenton-like reaction to assist DOX in killing cancer cells. DMTH NPs had high DOX loading efficiency for chemotherapeutic function and had the ability for photoacoustic imaging (PAI) and photothermal therapy (PTT) after being modified by TA. Specifically, DMTH NPs targeted tumors and had low toxicity in vivo. Ultimately, the released DOX and .OH cooperated in killing MCF-7 cells effectively in vitro. The enhanced and precise breast cancer treatment was achieved using a PAI-guided chemodynamic/chem o/photothermal synergistic therapy under laser irradiation in vivo. Overall, this work presented an
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页数：10
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