Radical medicine: treating ageing to cure disease

被引:200
作者
Finkel, T [1 ]
机构
[1] NHLBI, Cardiovasc Branch, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/nrm1763
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The incidence of many diseases rises sharply with age. Although clearly separable, ageing and certain age-related diseases might share common mechanisms. Cellular metabolism and subsequent generation of reactive oxygen species might contribute both to the rate at which we age and to our susceptibility to numerous chronic diseases, therefore therapies that directly target the ageing process might provide new ways to treat human diseases.
引用
收藏
页码:971 / 976
页数:7
相关论文
共 74 条
[1]   Asymmetric inheritance of oxidatively damaged proteins during cytokinesis [J].
Aguilaniu, H ;
Gustafsson, L ;
Rigoulet, M ;
Nyström, T .
SCIENCE, 2003, 299 (5613) :1751-1753
[2]   Oxidative stress in neurodegeneration: cause or consequence? [J].
Andersen, JK .
NATURE MEDICINE, 2004, 10 (07) :S18-S25
[3]   Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration [J].
Araki, T ;
Sasaki, Y ;
Milbrandt, J .
SCIENCE, 2004, 305 (5686) :1010-1013
[4]   Reactive oxygen generated by Nox1 triggers the angiogenic switch [J].
Arbiser, JL ;
Petros, J ;
Klafter, R ;
Govindajaran, B ;
McLaughlin, ER ;
Brown, LF ;
Cohen, C ;
Moses, M ;
Kilroy, S ;
Arnold, RS ;
Lambeth, JD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :715-720
[5]   Mitochondria, oxidants, and aging [J].
Balaban, RS ;
Nemoto, S ;
Finkel, T .
CELL, 2005, 120 (04) :483-495
[6]   Mitochondrial integrity and function in atherogenesis [J].
Ballinger, SW ;
Patterson, C ;
Knight-Lozano, CA ;
Burow, DL ;
Conklin, CA ;
Hu, ZY ;
Reuf, J ;
Horaist, C ;
Lebovitz, R ;
Hunter, GC ;
McIntyre, K ;
Runge, MS .
CIRCULATION, 2002, 106 (05) :544-549
[7]  
Barry-Lane PA, 2001, J CLIN INVEST, V108, P1513, DOI 10.1172/JCI200111927
[8]   HYDROGEN-PEROXIDE MEDIATES AMYLOID-BETA PROTEIN TOXICITY [J].
BEHL, C ;
DAVIS, JB ;
LESLEY, R ;
SCHUBERT, D .
CELL, 1994, 77 (06) :817-827
[9]   Calorie restriction, SIRT1 and metabolism: Understanding longevity [J].
Bordone, L ;
Guarente, L .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) :298-305
[10]   Molecular pathways to neurodegeneration [J].
Bossy-Wetzel, E ;
Schwarzenbacher, R ;
Lipton, SA .
NATURE MEDICINE, 2004, 10 (07) :S2-S9