Development of a tandem base-catalyzed, triphenylphosphine-mediated disulfide reduction-Michael addition

被引：28
作者：
Bartolozzi, Alessandra [1 ]
Foudoulakis, Hope M. [1 ]
Cole, Bridget M. [1 ]
机构：
[1] Surface Logix Inc, Brighton, MA 02135 USA
来源：
SYNTHESIS-STUTTGART | 2008年 / 13期
关键词：
Michael additions; reductions; thiols; triphenylphosphine; benzothiazepinones;
D O I：
10.1055/s-2008-1067102
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A tandem disulfide reduction-Michael addition was developed using both free and polymer-bound triphenylphosphine as the reducing agent. The procedure was applied to intermolecular systems for the synthesis of arylsulfanyl- and alkylsulfanyl- sub sti tuted propanoates and related ketones, and to an intramolecular system for the synthesis of a benzothiazepinone derivative.
引用
收藏
页码：2023 / 2032
页数：10
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