HDAC11 is a regulator of diverse immune functions

被引：81

作者：

Yanginlar, Cansu ^{[1
]}

Logie, Colin ^{[1
]}

机构：

[1] Radboud Inst Mol Life Sci, Dept Mol Biol, Nijmegen, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2018年 / 1861卷 / 01期

关键词：

HDAC11; Epigenetics; Immune system; HDACi; HUMAN HISTONE DEACETYLASE; VERSUS-HOST-DISEASE; RESISTANT LEISHMANIA-DONOVANI; DEPENDENT TRANSCRIPTION; EXPERIMENTAL-INFECTION; TRANSFORMED-CELLS; HYDROXAMIC ACID; T-CELLS; CLASS-I; CANCER;

D O I：

10.1016/j.bbagrm.2017.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone deacetylases deacetylate histone and non-histone protein targets. Aberrant HDAC expression and function have been observed in several diseases, which make these enzymes attractive treatment targets. Here, we summarize recent literature that addresses the roles of HDAC11 on the regulation of different immune cells including neutrophils, myeloid derived suppressor cells and T-cells. HDAC11 was initially identified as a negative regulator of the well-known anti-inflammatory cytokine IL-10. Hence, antagonizing HDAC11 activity may have anti-tumor potential, whereas activating HDAC11 may be useful to treat chronic inflammation or auto immunity. However, to anticipate biological side-effects of HDAC11 modulators, more molecular insights will be required.

引用

页码：54 / 59

页数：6

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