Combinatorial synthesis of heterocycles: Solid phase synthesis of 2-arylquinoline-4-carboxylic acid derivatives

被引：44
作者：
Gopalsamy, A
Pallai, PV
机构：
[1] Department of Rational Drug Design, Procept, Inc., Cambridge, MA 02139
[2] FMC Corporation, Discovery Research, Box 8, Princeton
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 06期
关键词：
D O I：
10.1016/S0040-4039(96)02456-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Doebner quinoline synthesis has been adopted to solid phase. Acylation of an amino acid coupled to the Rink polystyrene resin with pyruvyl chloride afforded the immobilized amide 11. Further reaction of 11 with the preformed Schiffs base 12 or aldehyde 3 and aniline 2 gave, after trifluoroacetic acid cleavage, 2-arylquinoline-4-carboxylic acid amides 14 in good yields. (C) 1997, Elsevier Science Ltd.
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页码：907 / 910
页数：4
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