WBN/Kob-Ht rats spontaneously develop dermatitis under conventional conditions:: Another possible model for atopic dermatitis

被引：17

作者：

Asakawa, M

Yoshioka, T

Hikita, I

Matsutani, T

Hirasawa, T

Arimura, A

Sakata, T

Horikawa, T

机构：

[1] Shionogi & Co Ltd, Shionogi Discovery Res Labs, Toyonaka, Osaka 5610825, Japan

[2] Tohoku Univ, Sch Med, Dept Cell Biol, Div Immunol & Embryol, Sendai, Miyagi 9808575, Japan

[3] Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Dermatol, Kobe, Hyogo 6500017, Japan

来源：

EXPERIMENTAL ANIMALS | 2005年 / 54卷 / 05期

关键词：

atopic dermatitis; DS-Nh mice; WBN/Kob-Ht rats;

D O I：

10.1538/expanim.54.461

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

WBN/Kob-Ht rats (Ht-rats) raised under conventional conditions spontaneously developed dermatitis. In this study, we carried out histopathological analysis to elucidate the pathological features of the dermatitis in Ht-rats. We then tried to detect Staphylococcus species recovered from the skin lesions of Ht-rats. We also measured the serum levels of total IgE, IL-4 and IFN-gamma in these rats. The histopathological data indicated that inflammatory cells had infiltrated the skin lesions. Staphylococcus aureus was recovered from the skin lesions, and the serum levels of total IgE and IL-4 were elevated in Ht-rats with dermatitis. These results suggest that dermatitis in Ht-rats is similar to that in the DS-Nh mice, which has recently been proposed as an animal model for human atopic dermatitis.

引用

页码：461 / 465

页数：5

共 19 条

[1] Locus of dominant hairless gene (Ht) causing abnormal hair and keratinization maps to rat chromosome 10 [J].