PTC in OPRD: An illustrative overview

被引：25

作者：

Ikunaka, Masaya ^{[1
]}

机构：

[1] Nagase & Co Ltd, Ctr Res & Dev, Nishi Ku, Kobe, Hyogo 6512241, Japan

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2008年 / 12卷 / 04期

关键词：

D O I：

10.1021/op700262h

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Illustrative examples of phase transfer catalysis (PTC) are compiled, albeit arbitrarily, to demonstrate its applicability to organic process research and development (OPRD), which covers eleven types of reactions: (1) ether formation, (2) ester formation, (3) hydrolytic removal of O-acetyl and O-silyl groups, (4) ester hydrolysis, (5) one-pot transesterification, (6) inorganic anionic species-mediated oxidation, (7) activation of KF for the fluoride-elicited nucleophilic displacement, (8) dichlorocarbene generation, (9) C-C bond formation in racemic synthesis, (10) asymmetric C-C bond formation in enantioselective synthesis of alpha-amino acids and alpha-hydroxy acids, and (11) enantio- and diasterocontrolled nitroaldol reactions.

引用

页码：698 / 709

页数：12

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