Association between GSTM1, GSTT1, and GSTP1 polymorphisms and lung cancer risk in a Turkish population

被引：34

作者：

Ada, Ahmet O. ^{[1
]}

Kunak, Semih C. ^{[2
]}

Hancer, Figen ^{[1
]}

Soydas, Emre ^{[1
]}

Alpar, Sibel ^{[3
]}

Gulhan, Meral ^{[3
]}

Iscan, Mumtaz ^{[1
]}

机构：

[1] Ankara Univ, Dept Toxicol, Fac Pharm, TR-06100 Ankara, Turkey

[2] Univ Giresun, Dept Pharmacol, Fac Med, Giresun, Turkey

[3] Ataturk Pulm Dis & Thorac Surg Hosp, Ankara, Turkey

来源：

MOLECULAR BIOLOGY REPORTS | 2012年 / 39卷 / 05期

关键词：

GST polymorphism; Lung cancer; Detoxification; GLUTATHIONE-S-TRANSFERASE; GENETIC POLYMORPHISMS; P1; POLYMORPHISMS; POOLED-ANALYSIS; NULL-GENOTYPE; SUSCEPTIBILITY; M1; SMOKING; T1; SUBTYPES;

D O I：

10.1007/s11033-011-1411-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several studies focused on investigating genetic polymorphisms in order to estimate genetic contribution to lung cancer often showed conflicting results. In this study, we investigated the role of GSTM1, GSTT1, GSTP1 exon 5 and exon 6 polymorphisms on developing lung cancer and histological subtypes in 213 lung cancer patients and 231 controls. GSTM1 null, GSTT1 null, and GSTP1 exon 5 variant genotypes did not show a significant risk for developing lung cancer overall. Significant association was noted between GSTP1 exon 6 variant genotypes and overall lung cancer risk (OR 2.17, 95% CI 1.25-3.78; P = 0.006). These results show that GSTP1 exon 6 polymorphism might be an important factor in determining lung cancer susceptibility in a Turkish population.

引用

页码：5985 / 5993

页数：9

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