Body Composition Findings by Computed Tomography in SARS-CoV-2 Patients: Increased Risk of Muscle Wasting in Obesity

被引:59
作者
Gualtieri, Paola [1 ]
Falcone, Carmela [2 ]
Romano, Lorenzo [3 ]
Macheda, Sebastiano [4 ]
Correale, Pierpaolo [5 ]
Arciello, Pietro [2 ]
Polimeni, Nicola [4 ]
De Lorenzo, Antonino [1 ]
机构
[1] Univ Roma Tor Vergata, Sect Clin Nutr & Nutrigen, Dept Biomed & Prevent, I-0133 Rome, Italy
[2] Grande Osped Metropolitano Bianchi Melacrino More, Radiol Unit, I-89124 Reggio Di Calabria, Italy
[3] Univ Roma Tor Vergata, Sch Specializat Food Sci, I-00133 Rome, Italy
[4] Grande Osped Metropolitano Bianchi Melacrino More, Unit Intens Care Med & Anesthesia, I-89124 Reggio Di Calabria, Italy
[5] Grande Osped Metropolitano Bianchi Melacrino More, Med Oncol Unit, I-89124 Reggio Di Calabria, Italy
关键词
diagnostic imaging; CT scan; body composition; fat; lean; liver attenuation; inflammation; muscle wasting; obesity; SKELETAL-MUSCLE; CRITICAL ILLNESS; FAT MASS; LIVER; METABOLISM; NUTRITION; LIGASES; STRESS; INDEX;
D O I
10.3390/ijms21134670
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Obesity is a characteristic of COVID-19 patients and the risk of malnutrition can be underestimated due to excess of fat: a paradoxical danger. Long ICU hospitalization exposes patients to a high risk of wasting and loss of lean body mass. The complex management precludes the detection of anthropometric parameters for the definition and monitoring of the nutritional status. The use of imaging diagnostics for body composition could help to recognize and treat patients at increased risk of wasting with targeted pathways. COVID-19 patients admitted to the ICU underwent computed tomography within 24 h and about 20 days later, to evaluate the parameters of the body and liver composition. The main results were the loss of the lean mass index and a greater increase in liver attenuation in obese subjects. These could be co-caused by COVID-19, prolonged bed rest, the complex medical nutritional therapy, and the starting condition of low-grade inflammation of the obese. The assessment of nutritional status, with body composition applied to imaging diagnostics and metabolic profiles in COVID-19, will assist in prescribing appropriate medical nutritional therapy. This will reduce recovery times and complications caused by frailty.
引用
收藏
页码:1 / 13
页数:12
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