Microbubbles in ultrasound-triggered drug and gene delivery

被引：861

作者：

Hernot, Sophie ^{[1
,2
]}

Klibanov, Alexander L. ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Med, Div Cardiovasc, Charlottesville, VA 22908 USA

[2] Vrije Univ Brussel, Lab In Vivo Cellular & Mol Imaging, Brussels, Belgium

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2008年 / 60卷 / 10期

关键词：

ultrasound; ultrasound contrast agent; molecular imaging; microbubbles; echo; acoustic; triggered release;

D O I：

10.1016/j.addr.2008.03.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ultrasound contrast agents, in the form of gas-filled microbubbles, are becoming popular in perfusion monitoring; they are employed as molecular imaging agents. Microbubbles are manufactured from biocompatible materials, they can be injected intravenously, and some are approved for clinical use. Microbubbles can be destroyed by ultrasound irradiation. This destruction phenomenon can be applied to targeted drug delivery and enhancement of drug action. The ultrasonic field can be focused at the target tissues and organs; thus, selectivity of the treatment can be improved, reducing undesirable side effects. Microbubbles enhance ultrasound energy deposition in the tissues and serve as cavitation nuclei, increasing intracellular drug delivery. DNA delivery and successful tissue transfection are observed in the areas of the body where ultrasound is applied after intravascular administration of microbubbles and plasmid DNA. Accelerated blood clot dissolution in the areas of insonation by cooperative action of thrombolytic agents and microbubbles is demonstrated in several clinical trials. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：1153 / 1166

页数：14