The Effects of Long-Term Omega-3 Fatty Acid Supplementation on Cognition and Alzheimer's Pathology in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-Analysis

被引：115

作者：

Hooijmans, Carlijn R. ^{[1
,2
]}

Pasker-de Jong, Pieternel C. M. ^{[3
]}

de Vries, Rob B. M. ^{[1
,2
]}

Ritskes-Hoitinga, Merel ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Cent Anim Lab, NL-6525 EZ Nijmegen, Netherlands

[2] 3R Res Ctr, NL-6525 EZ Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 EZ Nijmegen, Netherlands

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2012年 / 28卷 / 01期

关键词：

Alzheimer's disease; amyloid-beta peptides; animal models; cognition; docosahexaenoic acid; omega-3 fatty acids; pathology; systematic review; N-3; FATTY-ACIDS; BETA-INFUSED RATS; DOCOSAHEXAENOIC ACID; AMYLOID-BETA; FISH CONSUMPTION; TRANSGENIC MICE; MOUSE MODEL; DIETARY SUPPLEMENTATION; LEARNING-ABILITY; CLINICAL-TRIALS;

D O I：

10.3233/JAD-2011-111217

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To date, only a few randomized clinical trials (RCTs) have investigated the effects of omega-3 fatty acids (FA) on Alzheimer's disease (AD). Some of these studies demonstrated that patients with very mild AD or mild cognitive impairment benefit from omega-3 FA treatment, but none showed significant improvements in cognitive function in patients with moderate or advanced AD. All these RCTs had a relatively short duration of supplementation, however, and we hypothesized that this might be one of the reasons why no effects of omega-3 FA supplementation could be observed in patients with "moderate" or "advanced" AD. Animal studies offer better possibilities for controlled long-term supplementation than clinical studies. Therefore, we performed a systematic review (SR) and meta-analysis of the literature that focused on effects of the relatively long-term omega-3 FA supplementation (minimum period; 10% of average total lifespan) on cognitive impairment, amyloid-beta pathology, and neuronal loss in animal models of AD. This SR shows that long-term omega-3 FA supplementation decreased the omega-6/omega-3 FA ratio and reduced the amount of amyloid-beta in experimental animal models of AD. Omega-3 FA supplementation also improved cognitive function; this effect appeared larger in rats compared to mice, and in males compared to females. Moreover, omega-3 FA supplementation diminished the amount of neuronal loss, especially in female animals. The results of this SR indicate that it might be worthwhile to perform new clinical trials with long-term omega-3 FA supplementation in AD patients.

引用

页码：191 / 209

页数：19

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