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A spatial and temporal analysis of paediatric central nervous system infections from 2005 to 2015 in Ho Chi Minh City, Vietnam
被引:0
|作者:
Ho, N. T.
[1
]
Hoang, V. M. T.
[2
]
Le, N. N. T.
[3
]
Nguyen, D. T.
[4
]
Tran, A.
[5
]
Kaki, D.
[6
]
Tran, P. M.
[7
]
Thompson, C. N.
[7
]
Ngo, M. N. Q.
[3
]
Truong, K. H.
[3
]
Nguyen, H. T.
[3
]
Ha, T. M.
[2
]
Nguyen, C. V. V.
[4
]
Thwaites, G. E.
[7
,8
]
Thakur, K. T.
[1
]
Hesdorffer, D.
[1
]
Baker, S.
[7
,8
,9
]
机构:
[1] Columbia Univ, Med Ctr, New York, NY USA
[2] Childrens Hosp 2, Ho Chi Minh City, Vietnam
[3] Childrens Hosp 1, Ho Chi Minh City, Vietnam
[4] Hosp Trop Dis, Ho Chi Minh City, Vietnam
[5] St Louis Univ, St Louis, MO 63103 USA
[6] Princeton Univ, Princeton, NJ 08544 USA
[7] Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam
[8] Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England
[9] Univ Cambridge, Dept Med, Cambridge, England
基金:
英国惠康基金;
关键词:
Encephalitis;
epidemiology;
spatial temporal;
paediatric;
meningitis;
BACTERIAL-MENINGITIS;
COST-EFFECTIVENESS;
RISK-FACTORS;
ENCEPHALITIS;
CHILDREN;
MODELS;
D O I:
10.1017/S095026881700228X
中图分类号:
R1 [预防医学、卫生学];
学科分类号:
1004 ;
120402 ;
摘要:
Central nervous system infections (CNSI) are a leading cause of death and long-term disability in children. Using ICD-10 data from 2005 to 2015 from three central hospitals in Ho Chi Minh City (HCMC), Vietnam, we exploited generalized additive mixed models (GAMM) to examine the spatial-temporal distribution and spatial and climatic risk factors of paediatric CNSI, excluding tuberculous meningitis, in this setting. From 2005 to 2015, there were 9469 cases of paediatric CNSI; 33% were <= 1 year old at admission and were mainly diagnosed with presumed bacterial CNSI (BI) (79%), the remainder were >1 year old and mainly diagnosed with presumed non-bacterial CNSI (non-BI) (59%). The urban districts of HCMC in proximity to the hospitals as well as some outer districts had the highest incidences of BI and non-BI; BI incidence was higher in the dry season. Monthly BI incidence exhibited a significant decreasing trend over the study. Both BI and non-BI were significantly associated with lags in monthly average temperature, rainfall, and river water level. Our findings add new insights into this important group of infections in Vietnam, and highlight where resources for the prevention and control of paediatric CNSI should be allocated.
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页码:3307 / 3317
页数:11
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