Organic Carbamates in Drug Design and Medicinal Chemistry

被引：580

作者：

Ghosh, Arun K. ^{[1
]}

Brindisi, Margherita

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 58卷 / 07期

基金：

美国国家卫生研究院;

关键词：

HIV-1 PROTEASE INHIBITORS; GAMMA-SECRETASE INHIBITOR; ENZYME PRODRUG THERAPY; SOLID-PHASE SYNTHESIS; AMINOMETHYL)-1-CYCLOHEXANE ACETIC-ACID; TRIFLUOROMETHYL KETONE INHIBITORS; IMMUNODEFICIENCY-VIRUS PROTEASE; CYCLIZATION-ACTIVATED PRODRUGS; IMPROVED ORAL BIOAVAILABILITY; APPENDED N-ALKYLSULFONAMIDES;

D O I：

10.1021/jm501371s

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drugtarget interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry.

引用

页码：2895 / 2940

页数：46

共 340 条

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