Heart rate variability in rats with aldosterone-induced chronic heart failure

被引：0

作者：

Raphisak, P ^{[1
]}

Curry, ADJ ^{[1
]}

Malkin, RA ^{[1
]}

Schuckers, SAC ^{[1
]}

机构：

[1] W Virginia Univ, Lane Dept Comp Sci & Elect Engn, Morgantown, WV 26506 USA

来源：

PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH | 2003年 / 25卷

关键词：

aldosterone; electrocardiogram; heart rate variability; long-term recordings; rat;

D O I：

10.1109/IEMBS.2003.1279584

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The renin-angiotensin-aldosterone system contributes to the pathophysiology of chronic heart failure. In this study, chronic heart failure is gradually induced in uninephrectomized rats (n = 4) by aldosterone infusion (0.75 mug/h) and high Na and low Mg diet for four weeks followed up by high Na and low Mg diet alone for an additional six weeks. A control rat (n = 1) is untreated and unoperated. Electrocardiograms were recorded continuously during the entire experiment. Time and frequency domain heart rate variability (HRV) parameters are computed to study the long-term trends of heart rate and HRV. The results show that aldosterone infusion decreases heart rate and circadian variability in the treatment rats. After stopping aldosterone infusion, heart rate increases with less circadian variability. ANOVA indicates change of heart rate (p < 0.001) during and after aldosterone infusion periods (within each treatment rat).

引用

页码：228 / 231

页数：4

共 50 条

[31] Aldosterone-induced inflammation in the rat heart - Role of oxidative stress
Sun, Y
Zhang, JK
Lu, L
Chen, SS
Quinn, MT
Weber, KT
AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (05): : 1773 - 1781
[32] Heart rate variability and Diastolic heart failure
Arora, R
Krummerman, A
Vijayaraman, P
Rosengarten, M
Suryadevara, V
Lejemtel, T
Ferrick, KJ
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2004, 27 (03): : 299 - 303
[33] Metaiodobenzylguanidine and heart rate variability in heart failure
Kurata, C
Shouda, S
Mikami, T
Uehara, A
Ishikawa, K
Tawarahara, K
Nakano, T
Matoh, F
Takeuchi, K
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1998, 62 (10): : 770 - 772
[34] Heart rate variability in congestive heart failure
Tateishi, O
Shouda, T
Azuma, Y
Chin, K
Nogimura, T
Gotou, Y
Itou, T
Mochizuki, S
Machida, K
CLINICAL AND EXPERIMENTAL HYPERTENSION, 2002, 24 (1-2) : 75 - 81
[35] Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure
Yee, KM
Pringle, SD
Struthers, AD
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (07) : 1800 - 1807
[36] Heart rate normalization in the analysis of heart rate variability in congestive heart failure
Isler, Y.
Kuntalp, M.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, 2010, 224 (H3) : 453 - 463
[37] Reduction of heart rate, but not heart rate variability, in diabetic rats
Cupples, Will
Lau, Catherine
Obara, Robert
Koeners, Maarten
FASEB JOURNAL, 2009, 23
[38] Association between heart rate variability and haemodynamic response to exercise in chronic heart failure
Koshy, Aaron
Okwose, Nduka C.
Nunan, David
Toms, Anet
Brodie, David A.
Doherty, Patrick
Seferovic, Petar
Ristic, Arsen
Velicki, Lazar
Filipovic, Nenad
Popovic, Dejana
Skinner, Jane
Bailey, Kristian
MacGowan, Guy A.
Jakovljevic, Djordje G.
SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2019, 53 (02) : 77 - 82
[39] Reverse re-modelling chronic heart failure by reinstating heart rate variability
J. Shanks
Y. Abukar
N. A. Lever
M. Pachen
I. J. LeGrice
D. J. Crossman
A. Nogaret
J. F. R. Paton
R. Ramchandra
Basic Research in Cardiology, 2022, 117
[40] Subacute effects of maximal exercise on heart rate variability in patients with chronic heart failure
Soares, P.
Moreira, P.
Neves, F.
Rocha, N.
Nobrega, A.
CIRCULATION, 2008, 118 (12) : E490 - E490

← 1 2 3 4 5 →