Cp*Co(III)-Catalyzed Ketone-Directed ortho-C-H Activation for the Synthesis of Indene Derivatives

被引：21

作者：

Dethe, Dattatraya H. ^{[1
]}

Nagabhushana, C. B. ^{[1
]}

Bhat, Arsheed Ahmad ^{[1
]}

机构：

[1] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 11期

关键词：

REGIOSELECTIVE SYNTHESIS; BOND FUNCTIONALIZATIONS; CATALYZED CYCLIZATION; AROMATIC KETONES; CARBON-HYDROGEN; ARYL KETONES; RUTHENIUM; ANNULATION; ALKYNES; LIGAND;

D O I：

10.1021/acs.joc.0c00727

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A weakly coordinating, carbonyl-assisted C-H activation of aromatic systems with alpha,beta-unsaturated ketone and subsequent aldol condensation has been developed using a Cp*Co(CO)I-2 catalyst. The developed method is the first example of indene synthesis by cobalt-catalyzed C-H activation. In addition, the reaction requires mild reaction conditions and easily accessible starting materials, and it shows excellent functional group compatibility.

引用

页码：7565 / 7575

页数：11

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