High-throughput preparation of alkyl 4-aryl substituted-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylates under microwave irradiation

被引：5
作者：
Rodriguez, Hortensia [1 ,2 ]
Coro, Julieta [1 ]
Lam, Anabel [3 ]
Salfran, Esperanza [1 ]
Rodriguez-Salarichs, Javier [3 ]
Suarez, Margarita [1 ]
Albericio, Fernando [2 ,4 ,5 ]
Martin, Nazario [6 ]
机构：
[1] Univ La Habana, Fac Quim, Dept Quim Organ, Lab Sintesis Organ, Havana 10400, Cuba
[2] Inst Res Biomed, Barcelona 08028, Spain
[3] Univ Havana, Inst Mat Sci & Technol IMRE, Zeolite Engn Lab, Havana 10400, Cuba
[4] CIBER BBN, Networking Ctr Bioengn Biomat & Nanomed, Barcelona 08028, Spain
[5] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain
[6] Univ Complutense, Fac Ciencias Quim, Dept Quim Inorgan, E-28040 Madrid, Spain
来源：
ARKIVOC | 2011年
关键词：
Microwave irradiation; Lawesson's reagent; thiopyridones; theoretical calculation; heterocycles; ONE-POT SYNTHESIS; ORGANIC-SYNTHESIS; LAWESSONS REAGENT; TETRATHIAFULVALENE; COMBINATORIAL; DERIVATIVES; THIONATION; OVENS;
D O I：
10.3998/ark.5550190.0012.909
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient high-throughput synthesis of 4-aryl substituted 1,4,5,6-tetrahydro-2-methyl-6-thioxopyridine-3-carboxylates 5a-p was developed by using Lawesson's reagent, a very effective thionating reagent for carbonyl compounds, under conventional conditions and microwave irradiation, In order to gain a better understanding of the structure of the heterocycles obtained, theoretical calculations at the ab initio level were carried out
引用
收藏
页码：125 / +
页数：23
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