High-throughput preparation of alkyl 4-aryl substituted-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylates under microwave irradiation

被引：5

作者：

Rodriguez, Hortensia ^{[1
,2
]}

Coro, Julieta ^{[1
]}

Lam, Anabel ^{[3
]}

Salfran, Esperanza ^{[1
]}

Rodriguez-Salarichs, Javier ^{[3
]}

Suarez, Margarita ^{[1
]}

Albericio, Fernando ^{[2
,4
,5
]}

Martin, Nazario ^{[6
]}

机构：

[1] Univ La Habana, Fac Quim, Dept Quim Organ, Lab Sintesis Organ, Havana 10400, Cuba

[2] Inst Res Biomed, Barcelona 08028, Spain

[3] Univ Havana, Inst Mat Sci & Technol IMRE, Zeolite Engn Lab, Havana 10400, Cuba

[4] CIBER BBN, Networking Ctr Bioengn Biomat & Nanomed, Barcelona 08028, Spain

[5] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

[6] Univ Complutense, Fac Ciencias Quim, Dept Quim Inorgan, E-28040 Madrid, Spain

来源：

ARKIVOC | 2011年

关键词：

Microwave irradiation; Lawesson's reagent; thiopyridones; theoretical calculation; heterocycles; ONE-POT SYNTHESIS; ORGANIC-SYNTHESIS; LAWESSONS REAGENT; TETRATHIAFULVALENE; COMBINATORIAL; DERIVATIVES; THIONATION; OVENS;

D O I：

10.3998/ark.5550190.0012.909

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient high-throughput synthesis of 4-aryl substituted 1,4,5,6-tetrahydro-2-methyl-6-thioxopyridine-3-carboxylates 5a-p was developed by using Lawesson's reagent, a very effective thionating reagent for carbonyl compounds, under conventional conditions and microwave irradiation, In order to gain a better understanding of the structure of the heterocycles obtained, theoretical calculations at the ab initio level were carried out

引用

页码：125 / +

页数：23

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