Clostridium difficile caused changes in fatty acids profile and resolvin D1 content in plasma of infected patients

被引：1

作者：

Drozdz, Miroslaw ^{[1
]}

Gdula-Argasinska, Joanna ^{[2
]}

Biesiada, Grazyna ^{[3
]}

Jurczyszyn, Artur ^{[4
]}

Perucki, William ^{[5
]}

Wolkow, Pawel ^{[6
,7
]}

Borys, Agnieszka ^{[6
,7
]}

Sroczynska, Katarzyna ^{[2
]}

Zajac, Anna ^{[2
]}

Librowski, Tadeusz ^{[2
]}

Garlicki, Aleksander ^{[3
]}

Czepiel, Jacek ^{[3
]}

机构：

[1] St Anns Hosp, Miechow, Poland

[2] Jagiellonian Univ, Dept Radioligands, Fac Pharm, Med Coll, Krakow, Poland

[3] Jagiellonian Univ, Dept Infect & Trop Dis, Med Coll, Fac Med, Sniadeckich 5, PL-31501 Krakow, Poland

[4] Jagiellonian Univ, Fac Med, Dept Hematol, Med Coll, Krakow, Poland

[5] Univ Connecticut, John Dempsey Hosp, Dept Med, Farmington, CT 06032 USA

[6] Jagiellonian Univ, Med Coll, Ctr Med Genom OMICRON, Krakow, Poland

[7] Jagiellonian Univ, Med Coll, Dept Pharmacol, Fac Med, Krakow, Poland

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2020年 / 32卷 / 03期

关键词：

Clostridium difficile; fatty acids; pathogenesis; plasma; resolvin D1; LIPID MEDIATORS; SIGNIFICANTLY CORRELATE; MEMBRANE ORGANIZATION; RADIOLOGICAL EXTENT; ACUTE-INFLAMMATION; HDL-C; MECHANISMS; RESOLUTION; SERUM; N-3;

D O I：

10.1097/MEG.0000000000001600

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives Clostridium difficile infection (CDI) is an acute gastrointestinal infection caused by anaerobic, toxin-producing bacteria. During the course of CDI, there is a general inflammatory state. In order to gain a deeper understanding of the role of fatty acids (FAs) in the pathogenesis of acute infection we analyzed their plasma content in both patients with CDI and controls. Methods The study groups included 40 patients with CDI and 40 healthy volunteers. Plasma FA content was analyzed by gas chromatography, resolvin D1 (RvD1) level using ELISA assay, and we assessed the white blood cell (WBC) count, neutrophil count and C-reactive protein (CRP) level. Results Patients with CDI were characterized by significantly higher values of WBC, neutrophils, platelets and CRP compared with the control group. The saturated FA index was statistically higher and total n-3 FA was significantly decreased in the plasma of CDI patients as compared with the control group. RvD1 content was significantly higher in the control group as compared with patients with CDI. Conclusion In patients with good outcomes, we probably observed the effective resolution of inflammation, as reflected in n-3 FA metabolism and their significant decrease in plasma. This may indicate the therapeutic role of n-3 FA in CDI infection.

引用

页码：318 / 324

页数：7

共 41 条

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