Alterations in maternal and fetal heart functions accompany failed spiral arterial remodeling in pregnant mice

被引：14

作者：

Zhang, Jianhong ^{[1
]}

Adams, Michael A. ^{[2
]}

Croy, B. Anne ^{[1
]}

机构：

[1] Queens Univ, Dept Anat & Cell Biol, Kingston, ON, Canada

[2] Queens Univ, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6, Canada

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2011年 / 205卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

cardiovascular risk; fetal programming; lymphocyte biology; mouse pregnancy; preeclampsia; UTERINE ARTERY; BLOOD-PRESSURE; NK CELLS; MOUSE; PREDICTION; DOPPLER; ULTRASONOGRAPHY; DIFFERENTIATION; HEMODYNAMICS; HYPERTENSION;

D O I：

10.1016/j.ajog.2011.06.008

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Our goal was to define mechanisms that protect murine pregnancies deficient in spiral arterial remodeling from hypertension, hypoxia, and intrauterine growth restriction. STUDY DESIGN: Microultrasound analyses were conducted on virgin, gestation day 2, 4, 7, 9, 10, 12, 14, 16, 18, and postpartum BALB/c (wild type) mice and BALB/c-Rag2(-/-)/Il2rg(-/-) mice, an immunodeficient strain lacking spiral arterial remodeling. RESULTS: Rag2(-/-)/Il2rg(-/-) dams had normal spiral arterial flow velocities, greatly elevated uterine artery flow velocities between gestational day 10-16 and smaller areas of placental flow from gestational day 14 to term than controls. Maternal heart weight and output increased transiently. Conceptus alterations included higher flow velocities in the umbilical-placental circulation that became normal before term and bradycardia persistent to term. CONCLUSION: Transient changes in maternal heart weight and function accompanied by fetal circulatory changes successfully compensate for deficient spiral arterial modification in mice. Similar compensations may contribute to the elevated risk for cardiovascular diseases seen in women and their children who experience preeclamptic pregnancies.

引用

页码：485.e1 / 485.e16

页数：16

共 42 条

[11] Uterine and umbilical artery Doppler are comparable in predicting perinatal outcome of growth-restricted fetuses [J].

Ghosh, G. S. ;

Gudmundsson, S. .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2009, 116 (03) :424-430

[12] Decidual NK cells regulate key developmental processes at the human fetal-maternal interface [J].

Hanna, Jacob ;

Goldman-Wohl, Debra ;

Hamani, Yaron ;

Avraham, Inbal ;

Greenfield, Caryn ;

Natanson-Yaron, Shira ;

Prus, Diana ;

Cohen-Daniel, Leonor ;

Arnon, Tal I. ;

Manaster, Irit ;

Gazit, Roi ;

Yutkin, Vladimir ;

Benharroch, Daniel ;

Porgador, Angel ;

Keshet, Eli ;

Yagel, Simcha ;

Mandelboim, Ofer .

NATURE MEDICINE, 2006, 12 (09) :1065-1074

[13] Inflammation, Immunity, and Hypertension [J].

Harrison, David G. ;

Guzik, Tomasz J. ;

Lob, Heinrich E. ;

Madhur, Meena S. ;

Marvar, Paul J. ;

Thabet, Salim R. ;

Vinh, Antony ;

Weyand, Cornelia M. .

HYPERTENSION, 2011, 57 (02) :132-140

[14] Expression of the Vasoactive Proteins AT1, AT2, and ANP by Pregnancy-Induced Mouse Uterine Natural Killer Cells [J].

Hatta, Kota ;

Carter, Alexandra L. ;

Chen, Zhilin ;

Leno-Duran, Ester ;

Ruiz-Ruiz, Carmen ;

Olivares, Enrique G. ;

Tse, M. Yat ;

Pang, Stephen C. ;

Croy, B. Anne .

REPRODUCTIVE SCIENCES, 2011, 18 (04) :383-390

[15] Alpha 7 nicotinic acetylcholine receptor modulates lymphocyte activation [J].

Jose De Rosa, Maria ;

Dionisio, Leonardo ;

Agriello, Evangelina ;

Bouzat, Cecilia ;

del Carmen Esandi, Maria .

LIFE SCIENCES, 2009, 85 (11-12) :444-449

[16] Cardiovascular function in mice during normal pregnancy and in the absence of endothelial NO synthase [J].

Kulandavelu, Shathiyah ;

Qu, Dawei ;

Adamson, S. Lee .

HYPERTENSION, 2006, 47 (06) :1175-1182

[17] Recent progress toward the understanding of the pathophysiology of hypertension during preeclampsia [J].

LaMarca, Babbette D. ;

Gilbert, Jeffery ;

Granger, Joey P. .

HYPERTENSION, 2008, 51 (04) :982-988

[18] Functional role of uterine natural killer (uNK) cells in human early pregnancy decidua [J].

Lash, G. E. ;

Robson, S. C. ;

Bulmer, J. N. .

PLACENTA, 2010, 31 :S87-S92

[19] Fetal-Placental Hypoxia Does Not Result from Failure of Spiral Arterial Modification in Mice [J].

Leno-Duran, E. ;

Hatta, K. ;

Bianco, J. ;

Yamada, A. T. ;

Ruiz-Ruiz, C. ;

Olivares, E. G. ;

Croy, B. A. .

PLACENTA, 2010, 31 (08) :731-737

[20] Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring [J].

Mazzuca, Marc Q. ;

Wlodek, Mary E. ;

Dragomir, Nicoleta M. ;

Parkington, Helena C. ;

Tare, Marianne .

JOURNAL OF PHYSIOLOGY-LONDON, 2010, 588 (11) :1997-2010

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