Bipolarithizole A, an antifungal phenylthiazole-sativene merosesquiterpenoid from the potato endophytic fungus Bipolaris eleusines

被引:15
作者
Ai, Hong-Lian [1 ]
Shi, Bao-Bao [1 ]
Li, Wei [1 ]
He, Juan [1 ]
Li, Zheng-Hui [1 ]
Feng, Tao [1 ]
Liu, Ji-Kai [1 ]
机构
[1] South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China
基金
中国国家自然科学基金;
关键词
SESQUITERPENOIDS; CULTURES;
D O I
10.1039/d1qo01887f
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Bipolarithizole A (1), an unprecedented phenylthiazole-sativene sesquiterpenoid hybrid, has been isolated from cultures of the potato endophytic fungus Bipolaris eleusines. The structure with absolute configuration has been established by spectroscopic analysis and quantum chemical computational approaches, as well as by X-ray diffraction analysis. The plausible biosynthetic pathway for 1 has been proposed. Compound 1 shows anti-pathogenic fungi activity against Rhizoctonia solani with an MIC value of 16 mu g mL(-)(1).
引用
收藏
页码:1814 / 1819
页数:6
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