Myocardial contractility and body mass index in patients with coronary heart disease and type 2 diabetes mellitus

Aim. To investigate left and right ventricular (LV, RV) myocardial contractility in patients with coronary heart disease (CHD), Type 2 diabetes mellitus (DM-2), and various body mass index (BMI) levels. Material and methods. The study included 120 patients: 66 with CHD + DM-2 (Group I), and 54 with CHD only (Group II). All participants underwent standard clinical examination and balanced radioventriculography (BRVG). Results. In CHD and DM-2 patients with normal LV ejection fraction, EF (> 50%), regardless of obesity level, LV and RV diastolic dysfunction (decreased 1/3 diastolic filling) was observed, pointing to increased myocardial stiffness, compared with CHID individuals. In CHD, DM-2, and moderate obesity (IMT < 29 kg/m2), hyperkinetic contractility type was registered. Obesity progression was associated with significant increases in LV and RV volumes among CHD and DM-2 participants. Moreover, obesity progression was linked to substantial reduction in LV and RV inotropic function (reduced 1/3 systolic LV and RV output, decreased RV EF). Conclusion. In obesity progression, the most sensitive BRVG parameters were 1/3 systolic output, end-systolic and diastolic LV and RV volume, RV EF.