Hypoxia-inducible factors in cancer stem cells and inflammation

被引：108
作者：
Peng, Gong [1 ]
Liu, Yang [1 ,2 ]
机构：
[1] Jilin Univ, Hosp 1, Inst Translat Med, Changchun 130023, Peoples R China
[2] Childrens Natl Med Ctr, Childrens Res Inst, Ctr Canc & Immunol Res, Washington, DC 20010 USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2015年 / 36卷 / 06期
关键词：
leukemia-initiating cells; tumor microenvironment; myeloid-derived suppressor cells; dendritic cells; tumor-associated macrophages; cancer immunotherapy; ACUTE MYELOID-LEUKEMIA; ENDOTHELIAL GROWTH-FACTOR; ACUTE MYELOGENOUS LEUKEMIA; TUMOR-SUPPRESSOR GENE; MAMMALIAN TARGET; T-CELLS; MULTIDRUG-RESISTANCE; ANGIOGENIC SWITCH; IDH2; MUTATIONS; FACTOR-I;
D O I：
10.1016/j.tips.2015.03.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hypoxia-inducible factors (HIF) mediate metabolic switches in cells in hypoxic environments, including those in both normal and malignant tissues with limited supplies of oxygen. Paradoxically, recent studies have shown that cancer stem cells (CSCs) and activated immune effector cells exhibit high HIF activity in normoxic environments and that HIF activity is critical in the maintenance of CSCs as well as the differentiation and function of inflammatory cells. Given that inflammation and CSCs are two major barriers to effective cancer therapy, targeting HIF may provide a new approach to developing such treatments.
引用
收藏
页码：374 / 383
页数：10
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