Hypoxia-inducible factors in cancer stem cells and inflammation

被引：108

作者：

Peng, Gong ^{[1
]}

Liu, Yang ^{[1
,2
]}

机构：

[1] Jilin Univ, Hosp 1, Inst Translat Med, Changchun 130023, Peoples R China

[2] Childrens Natl Med Ctr, Childrens Res Inst, Ctr Canc & Immunol Res, Washington, DC 20010 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2015年 / 36卷 / 06期

关键词：

leukemia-initiating cells; tumor microenvironment; myeloid-derived suppressor cells; dendritic cells; tumor-associated macrophages; cancer immunotherapy; ACUTE MYELOID-LEUKEMIA; ENDOTHELIAL GROWTH-FACTOR; ACUTE MYELOGENOUS LEUKEMIA; TUMOR-SUPPRESSOR GENE; MAMMALIAN TARGET; T-CELLS; MULTIDRUG-RESISTANCE; ANGIOGENIC SWITCH; IDH2; MUTATIONS; FACTOR-I;

D O I：

10.1016/j.tips.2015.03.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypoxia-inducible factors (HIF) mediate metabolic switches in cells in hypoxic environments, including those in both normal and malignant tissues with limited supplies of oxygen. Paradoxically, recent studies have shown that cancer stem cells (CSCs) and activated immune effector cells exhibit high HIF activity in normoxic environments and that HIF activity is critical in the maintenance of CSCs as well as the differentiation and function of inflammatory cells. Given that inflammation and CSCs are two major barriers to effective cancer therapy, targeting HIF may provide a new approach to developing such treatments.

引用

页码：374 / 383

页数：10

共 50 条

[31] Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy [J].

Xiang, Lisha ;

Semenza, Gregg L. .

CANCER STEM CELLS, 2019, 141 :175-212

[32] PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia [J].

Maugeri, Grazia ;

D'Amico, Agata Grazia ;

Rasa, Daniela Maria ;

Saccone, Salvatore ;

Federico, Concetta ;

Cavallaro, Sebastiano ;

D'Agata, Velia .

NEUROPEPTIDES, 2018, 69 :84-91

[33] Pharmacologic Targeting of Hypoxia-Inducible Factors [J].

Semenza, Gregg L. .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59, 2019, 59 :379-403

[34] Regulation of erythropoiesis by hypoxia-inducible factors [J].

Haase, Volker H. .

BLOOD REVIEWS, 2013, 27 (01) :41-53

[35] Hypoxia-Inducible Factors in Physiology and Medicine [J].

Semenza, Gregg L. .

CELL, 2012, 148 (03) :399-408

[36] Endocrine targets of hypoxia-inducible factors [J].

Lee, Hsiu-Chi ;

Tsai, Shaw-Jenq .

JOURNAL OF ENDOCRINOLOGY, 2017, 234 (01) :R53-R65

[37] Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity [J].

Kietzmann, Thomas ;

Mennerich, Daniela ;

Dimova, ElitsaY. .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2016, 4

[38] Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications [J].

Yang, Liuqi ;

Lin, Caiyu ;

Wang, Li ;

Guo, Huijie ;

Wang, Xiujie .

EXPERIMENTAL CELL RESEARCH, 2012, 318 (19) :2417-2426

[39] Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine [J].

Cheloni, Giulia ;

Tanturli, Michele ;

Tusa, Ignazia ;

Ngoc Ho DeSouza ;

Shan, Yi ;

Gozzini, Antonella ;

Mazurier, Frederic ;

Rovida, Elisabetta ;

Li, Shaoguang ;

Dello Sbarba, Persio .

BLOOD, 2017, 130 (05) :655-665

[40] Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology [J].

Semenza, Gregg L. .

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9, 2014, 9 :47-71

← 1 2 3 4 5 →