cDNA cloning, chromosomal localization and evolutionary analysis of mouse vacuolar ATPase subunit D, Atp6m

被引：4

作者：

Kennell, JA ^{[1
]}

Richards, NW ^{[1
]}

Schaner, PE ^{[1
]}

Gumucio, DL ^{[1
]}

机构：

[1] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA

来源：

CYTOGENETICS AND CELL GENETICS | 2001年 / 92卷 / 3-4期

关键词：

D O I：

10.1159/000056924

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The multi-subunit vacuolar ATPase pump uses ATP hydrolysis to move protons into membrane bound compartments. The pump is involved in a variety of cellular functions, including regulation of cytosolic pH, vesicular transport, endocytosis, secretion, and apoptosis. Here, we describe the cDNA cloning and chromosomal mapping of subunit D of murine V-ATPase. The mouse gene, designated Atp6m, maps to Chromosome 12, in a region of high homology with human chromosome 14q24. Evolutionary analysis of subunit D orthologs in a variety of other species reveals that this is a highly conserved protein that has been under remarkably strong negative selection during evolution, most likely reflecting its critical role in multiple cellular processes. Copyright(C) 2001 S. Karger AG, Basel.

引用

页码：337 / 341

页数：5

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