Getting it right for children: improving tuberculosis treatment access and new treatment options

被引:24
作者
Brigden, Grania [1 ]
Furin, Jennifer [2 ]
Van Gulik, Clara [3 ]
Marais, Ben [4 ]
机构
[1] Medecins Sans Frontieres, Geneva, Switzerland
[2] Case Western Reserve Univ, TB Res Unit, Cleveland, OH 44106 USA
[3] Medecins Sans Frontieres, Tokyo, Japan
[4] Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur MBI, Sydney, NSW 2006, Australia
关键词
children; pediatric tuberculosis; prevention; treatment options; tuberculosis; MULTIDRUG-RESISTANT TUBERCULOSIS; HIV-INFECTED CHILDREN; CHILDHOOD TUBERCULOSIS; INTRATHORACIC TUBERCULOSIS; PULMONARY TUBERCULOSIS; PREVENTIVE THERAPY; AFRICAN CHILDREN; BCG VACCINATION; XPERT MTB/RIF; CONTACTS;
D O I
10.1586/14787210.2015.1015991
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Children were often the forgotten victims of the global tuberculosis (TB) epidemic, neglected by traditional TB services as well as maternal and child health initiatives. Luckily this is changing with a greater focus on children and the issues regarding their optimal management. A common misconception is that children with TB are always difficult to diagnose and treat. New diagnostic tools are urgently needed, but most children with TB in high-burden settings can be diagnosed with available approaches and treatment outcomes are generally excellent. Increased TB awareness, appropriate training of health care workers and inclusion in integrated management of childhood illness strategies will improve the access and quality of care that children receive. This review highlights what needs to be done to ensure that no child unnecessarily dies from TB and provides a brief overview of new advances in the field.
引用
收藏
页码:451 / 461
页数:11
相关论文
共 73 条
[41]  
Hesseling AC, 2009, SAMJ S AFR MED J, V99, P88
[42]   Outcome of HIV infected children with culture confirmed tuberculosis [J].
Hesseling, AC ;
Westra, AE ;
Werschkull, H ;
Donald, PR ;
Beyers, N ;
D Hussey, G ;
El-Sadr, W ;
Schaaf, HS .
ARCHIVES OF DISEASE IN CHILDHOOD, 2005, 90 (11) :1171-1174
[43]   Contact Investigation for Active Tuberculosis Among Child Contacts in Uganda [J].
Jaganath, Devan ;
Zalwango, Sarah ;
Okware, Brenda ;
Nsereko, Mary ;
Kisingo, Hussein ;
Malone, LaShaunda ;
Lancioni, Christina ;
Okwera, Alphonse ;
Joloba, Moses ;
Mayanja-Kizza, Harriet ;
Boom, W. Henry ;
Stein, Catherine ;
Mupere, Ezekiel .
CLINICAL INFECTIOUS DISEASES, 2013, 57 (12) :1685-1692
[44]   Childhood Tuberculosis and Malnutrition [J].
Jaganath, Devan ;
Mupere, Ezekiel .
JOURNAL OF INFECTIOUS DISEASES, 2012, 206 (12) :1809-1815
[45]   Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates [J].
Jenkins, Helen E. ;
Tolman, Arielle W. ;
Yuen, Courtney M. ;
Parr, Jonathan B. ;
Keshavjee, Salmaan ;
Perez-Velez, Carlos M. ;
Pagano, Marcello ;
Becerra, Mercedes C. ;
Cohen, Ted .
LANCET, 2014, 383 (9928) :1572-1579
[46]   Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis [J].
Mandalakas, A. M. ;
Detjen, A. K. ;
Hesseling, A. C. ;
Benedetti, A. ;
Menzies, D. .
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2011, 15 (08) :1018-1032
[47]   Modelling the cost-effectiveness of strategies to prevent tuberculosis in child contacts in a high-burden setting [J].
Mandalakas, Anna M. ;
Hesseling, Anneke C. ;
Gie, Robert P. ;
Schaaf, H. S. ;
Marais, Ben J. ;
Sinanovic, Edina .
THORAX, 2013, 68 (03) :247-255
[48]  
Marais B. J., 2011, Infectious Disorders - Drug Targets, V11, P144
[49]   Screening and Preventive Therapy for Tuberculosis [J].
Marais, Ben J. ;
Ayles, Helen ;
Graham, Stephen M. ;
Godfrey-Faussett, Peter .
CLINICS IN CHEST MEDICINE, 2009, 30 (04) :827-+
[50]  
Marais BJ, 2004, INT J TUBERC LUNG D, V8, P392