A glimpse at the metabolic research in China

被引:25
作者
Chen, Xiao-Wei [1 ,2 ]
Ding, Guangjin [3 ]
Xu, Li [4 ,5 ,6 ]
Li, Peng [4 ,5 ,6 ,7 ]
机构
[1] Peking Univ, Ctr Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Future Technol, Beijing 100871, Peoples R China
[3] Fudan Univ, Shanghai Key Lab Med Epigenet, Inst Biomed Sci, Shanghai 200032, Peoples R China
[4] Tsinghua Univ, State Key Lab Membrane Biol, Beijing 100084, Peoples R China
[5] Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Sch Life Sci, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China
[6] Shanghai Qi Zhi Inst, Shanghai 200030, Peoples R China
[7] Fudan Univ, Shanghai Key Lab Metab Remodeling & Hlth, Inst Metab & Integrat Biol, Shanghai, Peoples R China
基金
美国国家科学基金会;
关键词
BIOSYNTHESIS;
D O I
10.1016/j.cmet.2021.09.014
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Over the last few decades, China has witnessed a great leap in economic growth and social welfare. Unfortunately, Chinese people have also been affected by a pandemic of over-nutrition, lack of physical activity, and increasing prevalence of metabolic disorders including obesity, diabetes, non-alcohol fatty liver disease, and cardiovascular disease. For instance, China currently has the largest number of diabetic patients (-116 million) in the world. The fire of metabolic disorders is further fanned by the increased aging population, according to the survey results from the National Bureau of Statistics. On the other hand, progress in metabolic research has also made big strides. Here, we offer a glimpse at metabolic research in China, including not only its status quo but also its prospects, which aims to make significant contributions to our understanding of metabolism from bench to bedside.
引用
收藏
页码:2122 / 2125
页数:4
相关论文
共 16 条
[1]   The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals [J].
Cao, Yanan ;
Li, Lin ;
Xu, Min ;
Feng, Zhimin ;
Sun, Xiaohui ;
Lu, Jieli ;
Xu, Yu ;
Du, Peina ;
Wang, Tiange ;
Hu, Ruying ;
Ye, Zhen ;
Shi, Lixin ;
Tang, Xulei ;
Yan, Li ;
Gao, Zhengnan ;
Chen, Gang ;
Zhang, Yinfei ;
Chen, Lulu ;
Ning, Guang ;
Bi, Yufang ;
Wang, Weiqing .
CELL RESEARCH, 2020, 30 (09) :717-731
[2]   Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder [J].
Chen, Qi ;
Yan, Menghong ;
Cao, Zhonghong ;
Li, Xin ;
Zhang, Yunfang ;
Shi, Junchao ;
Feng, Gui-hai ;
Peng, Hongying ;
Zhang, Xudong ;
Zhang, Ying ;
Qian, Jingjing ;
Duan, Enkui ;
Zhai, Qiwei ;
Zhou, Qi .
SCIENCE, 2016, 351 (6271) :397-400
[3]   Crystal structure of the human glucose transporter GLUT1 [J].
Deng, Dong ;
Xu, Chao ;
Sun, Pengcheng ;
Wu, Jianping ;
Yan, Chuangye ;
Hu, Mingxu ;
Yan, Nieng .
NATURE, 2014, 510 (7503) :121-+
[4]   Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites [J].
Gong, Jingyi ;
Sun, Zhiqi ;
Wu, Lizhen ;
Xu, Wenyi ;
Schieber, Nicole ;
Xu, Dijin ;
Shui, Guanghou ;
Yang, Hongyuan ;
Parton, Robert G. ;
Li, Peng .
JOURNAL OF CELL BIOLOGY, 2011, 195 (06) :953-963
[5]   Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice [J].
Hu, Sumei ;
Wang, Lu ;
Yang, Dengbao ;
Li, Li ;
Togo, Jacques ;
Wu, Yingga ;
Liu, Quansheng ;
Li, Baoguo ;
Li, Min ;
Wang, Guanlin ;
Zhang, Xueying ;
Niu, Chaoqun ;
Li, Jianbo ;
Xu, Yanchao ;
Couper, Elspeth ;
Whittington-Davies, Andrew ;
Mazidi, Mohsen ;
Luo, Lijuan ;
Wang, Shengnan ;
Douglas, Alex ;
Speakman, John R. .
CELL METABOLISM, 2018, 28 (03) :415-+
[6]   Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma [J].
Jiang, Ying ;
Sun, Aihua ;
Zhao, Yang ;
Ying, Wantao ;
Sun, Huichuan ;
Yang, Xinrong ;
Xing, Baocai ;
Sun, Wei ;
Ren, Liangliang ;
Hu, Bo ;
Li, Chaoying ;
Zhang, Li ;
Qin, Guangrong ;
Zhang, Menghuan ;
Chen, Ning ;
Zhang, Manli ;
Huang, Yin ;
Zhou, Jinan ;
Zhao, Yan ;
Liu, Mingwei ;
Zhu, Xiaodong ;
Qiu, Yang ;
Sun, Yanjun ;
Huang, Cheng ;
Yan, Meng ;
Wang, Mingchao ;
Liu, Wei ;
Tian, Fang ;
Xu, Huali ;
Zhou, Jian ;
Wu, Zhenyu ;
Shi, Tieliu ;
Zhu, Weimin ;
Qin, Jun ;
Xie, Lu ;
Fan, Jia ;
Qian, Xiaohong ;
He, Fuchu ;
Zhu, Yunping ;
Wang, Yi ;
Yang, Dong ;
Liu, Wanlin ;
Liu, Qiongming ;
Yang, Xiaoming ;
Zhen, Bei ;
Wu, Zhenyu ;
Fan, Jia ;
Sun, Huichuan ;
Qian, Juying ;
Hong, Tao .
NATURE, 2019, 567 (7747) :257-+
[7]   Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice [J].
Lin, Zhuofeng ;
Tian, Haishan ;
Lam, Karen S. L. ;
Lin, Shaoqiang ;
Hoo, Ruby C. L. ;
Konishi, Morichika ;
Itoh, Nobuyuki ;
Wang, Yu ;
Bornstein, Stefan R. ;
Xu, Aimin ;
Li, Xiaokun .
CELL METABOLISM, 2013, 17 (05) :779-789
[8]   Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis [J].
Lu, Xiao-Yi ;
Shi, Xiong-Jie ;
Hu, Ao ;
Wang, Ju-Qiong ;
Ding, Yi ;
Jiang, Wei ;
Sun, Ming ;
Zhao, Xiaolu ;
Luo, Jie ;
Qi, Wei ;
Song, Bao-Liang .
NATURE, 2020, 588 (7838) :479-+
[9]   A metagenome-wide association study of gut microbiota in type 2 diabetes [J].
Qin, Junjie ;
Li, Yingrui ;
Cai, Zhiming ;
Li, Shenghui ;
Zhu, Jianfeng ;
Zhang, Fan ;
Liang, Suisha ;
Zhang, Wenwei ;
Guan, Yuanlin ;
Shen, Dongqian ;
Peng, Yangqing ;
Zhang, Dongya ;
Jie, Zhuye ;
Wu, Wenxian ;
Qin, Youwen ;
Xue, Wenbin ;
Li, Junhua ;
Han, Lingchuan ;
Lu, Donghui ;
Wu, Peixian ;
Dai, Yali ;
Sun, Xiaojuan ;
Li, Zesong ;
Tang, Aifa ;
Zhong, Shilong ;
Li, Xiaoping ;
Chen, Weineng ;
Xu, Ran ;
Wang, Mingbang ;
Feng, Qiang ;
Gong, Meihua ;
Yu, Jing ;
Zhang, Yanyan ;
Zhang, Ming ;
Hansen, Torben ;
Sanchez, Gaston ;
Raes, Jeroen ;
Falony, Gwen ;
Okuda, Shujiro ;
Almeida, Mathieu ;
LeChatelier, Emmanuelle ;
Renault, Pierre ;
Pons, Nicolas ;
Batto, Jean-Michel ;
Zhang, Zhaoxi ;
Chen, Hua ;
Yang, Ruifu ;
Zheng, Weimou ;
Li, Songgang ;
Yang, Huanming .
NATURE, 2012, 490 (7418) :55-60
[10]   Biosynthesis, regulation, and domestication of bitterness in cucumber [J].
Shang, Yi ;
Ma, Yongshuo ;
Zhou, Yuan ;
Zhang, Huimin ;
Duan, Lixin ;
Chen, Huiming ;
Zeng, Jianguo ;
Zhou, Qian ;
Wang, Shenhao ;
Gu, Wenjia ;
Liu, Min ;
Ren, Jinwei ;
Gu, Xingfang ;
Zhang, Shengping ;
Wang, Ye ;
Yasukawa, Ken ;
Bouwmeester, Harro J. ;
Qi, Xiaoquan ;
Zhang, Zhonghua ;
Lucas, William J. ;
Huang, Sanwen .
SCIENCE, 2014, 346 (6213) :1084-1088