Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells

被引：7

作者：

Nakamura, Takehiro ^{[1
,2
]}

Yoshida, Eiko ^{[1
]}

Fujie, Tomoya ^{[3
]}

Ogata, Fumihiko ^{[2
]}

Yamamoto, Chika ^{[3
]}

Kawasaki, Naohito ^{[2
]}

Kaji, Toshiyuki ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, 2641 Yamazaki, Noda, Chiba 2788510, Japan

[2] Kindai Univ, Fac Pharm, 3-4-1 Kowakae, Higashiosaka, Osaka 5778502, Japan

[3] Toho Univ, Fac Pharmaceut Sci, 2-2-1 Miyama, Funabashi, Chiba 2748510, Japan

来源：

JOURNAL OF TOXICOLOGICAL SCIENCES | 2017年 / 42卷 / 06期

关键词：

Copper complex; Cytotoxicity; Endothelial cell; Organic-inorganic hybrid molecule; Bio-organometallics; DIETHYLDITHIOCARBAMATE; METALLOTHIONEIN; ACID;

D O I：

10.2131/jts.42.683

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Organic-inorganic hybrid molecules, which are composed of organic-ligand(s) and metal(s), are indispensable as synthetic reagents in chemistry, but they have made very little in the way of contributions to biological research. Previously, we reported that the cytotoxicity of organic-inorganic hybrid molecules in vascular endothelial cells depends on interactions between the intramolecular metal and ligand, but remains independent of the hydrophobicity of the intramolecular metal(s). Herein, we show a synergistic cytotoxicity produced by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in vascular endothelial cells that depends on the intracellular accumulation of copper.

引用

收藏

页码：683 / 687

页数：5

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