Introduction: Inpatient treatment of acute bacterial skin and skin structure infections (ABSSSIs) exerts a significant economic burden on the healthcare system. Oritavancin is a concentration-dependent, rapid bactericidal agent approved for the treatment of ABSSSIs. Its prolonged half-life with one-time intravenous (i.v.) dosing offers a potential solution to this burden. In addition, oritavancin represents an alternative therapy for Streptococci and multidrug-resistant Gram-positive bacteria including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. Animal models have also shown promising results with oritavancin for other disease states including those that require long courses of i.v. therapy. Areas covered: This review covers oritavancin's basic chemistry, spectrum of activity, pharmacodynamics/pharmacokinetics and efficacy in clinical trials, and provides expert opinion on future directions. To compose this review, a search of PubMed was performed, and articles written in the English language were selected based on full text availability. Expert opinion: If oritavancin is proven to be a cost-effective strategy for outpatient treatment and prevents complications of prolonged i.v. therapy, it will be sought as an alternative antibiotic therapy for ABSSSIs. In addition, further clinical data demonstrating efficacy in Gram-positive infections requiring prolonged therapy such as endocarditis and osteomyelitis could support oritavancin's success in the current market.
机构:
Harbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USAHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Baquir, Beverlie
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Lemaire, Sandrine
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Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, BelgiumHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Lemaire, Sandrine
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Van Bambeke, Francoise
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Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, BelgiumHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Van Bambeke, Francoise
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Tulkens, Paul M.
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h-index: 0
机构:
Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, BelgiumHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Tulkens, Paul M.
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Lin, Lin
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机构:
Harbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USAHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Lin, Lin
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Spellberg, Brad
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h-index: 0
机构:
Harbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USAHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
机构:
Tufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Tufts Univ, Sch Med, Boston, MA 02111 USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Boucher, Helen W.
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Wilcox, Mark
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Leeds Teaching Hosp, Dept Microbiol, Leeds, W Yorkshire, England
Univ Leeds, Old Med Sch, Leeds, W Yorkshire, EnglandTufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Wilcox, Mark
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Talbot, George H.
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h-index: 0
机构:
Talbot Advisors, Anna Maria, FL USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Talbot, George H.
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Puttagunta, Sailaja
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机构:
Durata Therapeut, Branford, CT USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Puttagunta, Sailaja
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Das, Anita F.
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InClin, San Mateo, CA USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Das, Anita F.
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Dunne, Michael W.
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h-index: 0
机构:
Durata Therapeut, Branford, CT USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
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Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
San Francisco Gen Hosp, Div Infect Dis, San Francisco, CA 94110 USAUniv Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
机构:
Harbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USAHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Baquir, Beverlie
;
Lemaire, Sandrine
论文数: 0引用数: 0
h-index: 0
机构:
Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, BelgiumHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Lemaire, Sandrine
;
Van Bambeke, Francoise
论文数: 0引用数: 0
h-index: 0
机构:
Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, BelgiumHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Van Bambeke, Francoise
;
Tulkens, Paul M.
论文数: 0引用数: 0
h-index: 0
机构:
Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, BelgiumHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Tulkens, Paul M.
;
Lin, Lin
论文数: 0引用数: 0
h-index: 0
机构:
Harbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USAHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Lin, Lin
;
Spellberg, Brad
论文数: 0引用数: 0
h-index: 0
机构:
Harbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USAHarbor Univ Calif Los Angeles UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Gen Internal Med, Los Angeles, CA USA
机构:
Tufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Tufts Univ, Sch Med, Boston, MA 02111 USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Boucher, Helen W.
;
Wilcox, Mark
论文数: 0引用数: 0
h-index: 0
机构:
Leeds Teaching Hosp, Dept Microbiol, Leeds, W Yorkshire, England
Univ Leeds, Old Med Sch, Leeds, W Yorkshire, EnglandTufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Wilcox, Mark
;
Talbot, George H.
论文数: 0引用数: 0
h-index: 0
机构:
Talbot Advisors, Anna Maria, FL USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Talbot, George H.
;
Puttagunta, Sailaja
论文数: 0引用数: 0
h-index: 0
机构:
Durata Therapeut, Branford, CT USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Puttagunta, Sailaja
;
Das, Anita F.
论文数: 0引用数: 0
h-index: 0
机构:
InClin, San Mateo, CA USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
Das, Anita F.
;
Dunne, Michael W.
论文数: 0引用数: 0
h-index: 0
机构:
Durata Therapeut, Branford, CT USATufts Med Ctr, Div Infect Dis & Geog Med, Boston, MA 02111 USA
机构:
Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
San Francisco Gen Hosp, Div Infect Dis, San Francisco, CA 94110 USAUniv Calif San Francisco, Dept Med, San Francisco, CA 94143 USA