Onconeural antibodies: Improved detection and clinical correlations

被引：27

作者：

Storstein, Anette ^{[1
,2
]}

Monstad, Sissel Evy ^{[2
]}

Haugen, Mette ^{[1
]}

Mazengia, Kibret ^{[2
]}

Veltman, Dana ^{[1
]}

Lohndal, Emilia ^{[1
]}

Aarseth, Jan ^{[1
]}

Vedeler, Christian ^{[1
,2
]}

机构：

[1] Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway

[2] Univ Bergen, Dept Clin Med, N-5020 Bergen, Norway

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 232卷 / 1-2期

关键词：

Paraneoplastic neurological syndrome; Onconeural antibodies; Antibody detection; PARANEOPLASTIC NEUROLOGICAL SYNDROMES; CELL LUNG-CANCER; ANTINEURONAL ANTIBODIES; CEREBELLAR DEGENERATION; YO ANTIBODIES; HU; REGRESSION; CARCINOMA;

D O I：

10.1016/j.jneuroim.2010.10.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Onconeural antibodies are found in many patients with paraneoplastic neurological syndromes (PNS) and define the disease as paraneoplastic. The study describes the presence of onconeural antibodies and PNS in 555 patients with neurological symptoms and confirmed cancer within five years, and compares the diagnostic accuracy of different antibody assays (immunoprecipitation, immunofluorescence and immunoblot). Onconeural antibodies were found in 11.9% of the patients by immunoprecipitation, in 7.0% by immunofluorescence and in 6.3% by immunoblot. PNS were present in 81.8% of the cancer patients that were seropositive by immunoprecipitation. Immunofluorescence and immunoblot failed to detect onconeural antibodies in almost one third of the PNS cases. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：166 / 170

页数：5

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