Immunohistochemical Study of TGF-β1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma: Correlations Between Clinicopathologic Factors and Overall Survival

被引：7

作者：

Wagner, Vivian P. ^{[1
]}

Cardoso, Paula R. ^{[1
]}

dos Santos, Jean N. ^{[3
]}

Meurer, Luise ^{[2
]}

Vargas, Pablo A. ^{[4
]}

Fonseca, Felipe P. ^{[4
]}

Carrard, Vinicius C. ^{[1
]}

Martins, Manoela D. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Oral Pathol, Sch Dent, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Pathol, Sch Med, Porto Alegre, RS, Brazil

[3] Univ Fed Bahia, Sch Dent, Dept Oral Pathol, Lab Oral Surg Pathol, Salvador, BA, Brazil

[4] Univ Estadual Campinas, Dept Oral Diag, Piracicaba Dent Sch, Piracicaba, SP, Brazil

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2017年 / 25卷 / 09期

关键词：

head and neck cancer; proliferative labeling index; oral cancer; oral potentially malignant disorders; immunohistochemistry; GROWTH-FACTOR-BETA; TGF-BETA; PROGNOSTIC VALUE; IN-VIVO; CANCER; HEAD; MYOFIBROBLASTS; CARCINOGENESIS; PROGRESSION; EXPRESSION;

D O I：

10.1097/PAI.0000000000000355

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The aim of the present study was to analyze transforming growth factor beta 1 (TGF-beta 1) expression in cases of leukoplakia and oral squamous cell carcinoma (OSCC) and to correlate these expression profiles with proliferative labeling index, clinicopathologic factors, and clinical outcome. Clinical data for 24 cases of leukoplakia and 87 cases of OSCC were retrieved from medical records. OSCC tissues were included into tissue microarray blocks and sections of normal mucosa, leukoplakia, and OSCC tissue microarray's were prepared on slides. Immunohistochemistry was used to detect expression of TGF-beta 1 and Ki67. The expression of TGF-beta 1 and Ki67 were significantly increased from normal mucosa, through leukoplakia to OSCC. High expression of TGF-beta 1 correlated with an increase in proliferative labeling index. No association between TGF-beta 1 expression and the clinicopathologic factors examined was observed. Expression of TGF-beta 1 also did not associate with clinical outcome in either of groups. Our results suggest that changes in TGF-beta 1 are associated with the progression of oral carcinogenesis.

引用

页码：651 / 659

页数：9