Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies

被引：31
|
作者：
Deiana, Marco [1 ]
Matczyszyn, Katarzyna [1 ]
Massin, Julien [2 ]
Olesiak-Banska, Joanna [1 ]
Andraud, Chantal [2 ]
Samoc, Marek [1 ]
机构：
[1] Wroclaw Univ Technol, Fac Chem, Adv Mat Engn & Modelling Grp, PL-50370 Wroclaw, Poland
[2] Univ Lyon 1, Ecole Normale Super Lyon, CNRS UMR 5182, Lab Chim, F-69365 Lyon, France
来源：
PLOS ONE | 2015年 / 10卷 / 06期
关键词：
HUMAN HOLO-TRANSFERRIN; HUMAN SERUM-ALBUMIN; PROTEIN INTERACTIONS; BINDING MECHANISM; ETHIDIUM-BROMIDE; FLUORESCENCE; ABSORPTION; COMPLEXES; MODE; TAMOXIFEN;
D O I：
10.1371/journal.pone.0129817
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophorone/DNA adducts was found to be 1:1. The fluorescence quenching data revealed a binding interaction with the base pairs of DNA. The CD data indicate that all the investigated isophorones induce DNA modifications.
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收藏
页数：11
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