Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies

被引：33

作者：

Deiana, Marco ^{[1
]}

Matczyszyn, Katarzyna ^{[1
]}

Massin, Julien ^{[2
]}

Olesiak-Banska, Joanna ^{[1
]}

Andraud, Chantal ^{[2
]}

Samoc, Marek ^{[1
]}

机构：

[1] Wroclaw Univ Technol, Fac Chem, Adv Mat Engn & Modelling Grp, PL-50370 Wroclaw, Poland

[2] Univ Lyon 1, Ecole Normale Super Lyon, CNRS UMR 5182, Lab Chim, F-69365 Lyon, France

来源：

PLOS ONE | 2015年 / 10卷 / 06期

关键词：

HUMAN HOLO-TRANSFERRIN; HUMAN SERUM-ALBUMIN; PROTEIN INTERACTIONS; BINDING MECHANISM; ETHIDIUM-BROMIDE; FLUORESCENCE; ABSORPTION; COMPLEXES; MODE; TAMOXIFEN;

D O I：

10.1371/journal.pone.0129817

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophorone/DNA adducts was found to be 1:1. The fluorescence quenching data revealed a binding interaction with the base pairs of DNA. The CD data indicate that all the investigated isophorones induce DNA modifications.

引用

页数：11

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