Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse

被引：390
作者：
Serizawa, S
Miyamichi, K
Nakatani, H
Suzuki, M
Saito, M
Yoshihara, Y
Sakano, H [1 ]
机构：
[1] Univ Tokyo, Grad Sch Sci, Dept Biophys & Biochem, Tokyo 1130032, Japan
[2] Japan Sci & Technol Corp, CREST Programs, Kawaguchi, Saitama 3320012, Japan
[3] Kumamoto Univ, Ctr Anim Resources & Dev, Kumamoto 8620976, Japan
[4] RIKEN, Brain Sci Inst, Lab Neurobiol Synapse, Wako, Saitama 3510198, Japan
来源：
SCIENCE | 2003年 / 302卷 / 5653期
关键词：
D O I：
10.1126/science.1089122
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses only one odorant receptor (OR) gene in a monoallelic and mutually exclusive manner. Such expression forms the genetic basis for OR-instructed axonal projection of OSNs to the olfactory bulb of the brain during development. Here, we identify an upstream cis-acting DNA region that activates the OR gene cluster in mouse and allows the expression of only one OR gene within the cluster. Deletion of the coding region of the expressed OR gene or a naturally occurring frame-shift mutation allows a second OR gene to be expressed. We propose that stochastic activation of only one OR gene within the cluster and negative feedback regulation by that OR gene product are necessary to ensure the one receptor - one neuron rule.
引用
收藏
页码：2088 / 2094
页数：7
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