Postsplenectomy type-1 hypersensitivity response: A correlation between IL-4 and IgE serum levels

被引：0

作者：

Miniello, Stefano ^{[1
]}

Cristallo, Graziana ^{[1
]}

Testini, Mario ^{[2
]}

Balzanelli, Mario Giosue ^{[3
]}

Marzaioli, Rinaldo ^{[2
]}

Venezia, Pietro ^{[1
,2
,3
]}

Lissidini, Germana ^{[2
]}

Petrozza, Dino ^{[2
]}

Nacchiero, Michele ^{[2
]}

机构：

[1] Univ Bari, Sect Emergency & Trauma Surg, Dept Applicat Surg Innovat Technol, Med Sch Policlin, I-70124 Bari, Italy

[2] Univ Bari, Sect Gen Surg & Clin Oncol, Dept Applicat Surg Innovat Technol, Sch Med, I-70124 Bari, Italy

[3] Univ Bari, Postgrad Sch Thorac Surg, Sch Med, I-70124 Bari, Italy

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2008年 / 30卷 / 01期

关键词：

allergy; IgE; interleukin-4; splenectomy; trauma;

D O I：

10.1080/08923970701812597

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Authors demonstrated the presence of allergic manifestations in splenectomized patients following traumatic rupture of this organ. In particular, allergic diathesis, as supported by serum IgE increase, was exclusively found in patients with preserved T helper (h)-2 lymphocyte function. Th-2 function was monitored by measuring serum levels of interleukin (IL)-4, a cytokine involved in IgE synthesis. On the opposite, in splenectomized individuals with a reduced Th-2 function as supported by lower IL-4 serum levels, no IgE increase and allergic manifestations were detectable. On these grounds, authors hypothesize that allergic manifestations may be correlated to splenectomy since its exeresis may favor the persistence of antigens in the blood. Consequentially, in patients with a preserved Th-2 function, antigenic overload may lead to IgE increase and allergy onset.

引用

页码：71 / 77

页数：7

共 24 条

[1] Splenectomy and sepsis: The role of the spleen in the immune-mediated bacterial clearance [J].