Toll-like receptor signaling in the ischemic heart

被引：0

作者：

Frantz, Stefan ^{[1
]}

Ertl, Georg ^{[1
]}

Bauersachs, Johann ^{[1
]}

机构：

[1] Univ Wurzburg, Med Klin & Poliklin 1, Univ Klinikum Wurzburg, Herzkreislauf Zentrum, D-97080 Wurzburg, Germany

来源：

FRONTIERS IN BIOSCIENCE | 2008年 / 13卷

关键词：

TLR; innate immunity; myocardium; ischemic injury; heart failure; review;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll-like receptors (TLRs) have been identified as primary innate immune receptors. They distinguish among different patterns of pathogens and rapidly activate an innate immune response. However, TLRs can also be stimulated by host-derived molecules. TLRs are expressed in the cardiovascular system and could thus be a key link between cardiovascular diseases and the immune system. Increasing evidence suggests that TLR signaling promotes injury in the heart after ischemia, ischemia/reperfusion or hypertrophic stimuli. Herein we review the experimental and clinical evidence for the involvement of TLR and its downstream signaling molecules in cardiac ischemic injury.

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收藏

页码：5772 / 5779

页数：8

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