Review of the molecular profile and modern prognostic markers for gastric lymphoma: How do they affect clinical practice?

被引：12
作者：
Alevizos, Leonidas [1 ]
Gomatos, Ilias P. [1 ]
Smparounis, Spyridon [1 ]
Konstadoulakis, Manousos M. [1 ]
Zografos, Georgios [1 ]
机构：
[1] Hippokrateion Hosp, Athens Med Sch, Dept Propaedeut Surg 1, Athens 11527, Greece
来源：
CANADIAN JOURNAL OF SURGERY | 2012年 / 55卷 / 02期
关键词：
NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMA; QUANTITATIVE IMMUNOCYTOCHEMICAL ASSAYS; GASTROINTESTINAL STROMAL TUMOR; LOW-GRADE; HELICOBACTER-PYLORI; MALT-LYMPHOMA; MICROSATELLITE INSTABILITY; ADHESION MOLECULES; PROTEIN EXPRESSION;
D O I：
10.1503/cjs.002310
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Primary gastric lymphoma is a rare cancer of the stomach with an indeterminate prognosis. Recently, a series of molecular prognostic markers has been introduced to better describe this clinical entity. This review describes the clinical importance of several oncogenes, apoptotic genes and chromosomal mutations in the initiation and progress of primary non-Hodgkin gastric lymphoma and their effect on patient survival. We also outline the prognostic clinical importance of certain cellular adhesion molecules, such as ICAM and PECAM-1, in patients with gastric lymphoma, and we analyze the correlation of these molecules with apoptosis, angiogenesis, tumour growth and metastatic potential. We also focus on the host-immune response and the impact of Helicobacter pylori infection on gastric lymphoma development and progression. Finally, we explore the therapeutic methods currently available for gastric lymphoma, comparing the traditional invasive approach with more recent conservative options, and we stress the importance of the application of novel molecular markers in clinical practice.
引用
收藏
页码：117 / 124
页数：8
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