Reflective afocal broadband adaptive optics scanning ophthalmoscope

被引:270
作者
Dubra, Alfredo [1 ]
Sulai, Yusufu [2 ]
机构
[1] Univ Rochester, Flaum Eye Inst, Rochester, NY 14642 USA
[2] Univ Rochester, Inst Opt, Rochester, NY 14627 USA
来源
BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 06期
关键词
LIVING HUMAN RETINA; COHERENCE TOMOGRAPHY; HIGH-RESOLUTION; LASER OPHTHALMOSCOPY; CHROMATIC ABERRATION; EYE;
D O I
10.1364/BOE.2.001757
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A broadband adaptive optics scanning ophthalmoscope (BAOSO) consisting of four afocal telescopes, formed by pairs of off-axis spherical mirrors in a non-planar arrangement, is presented. The non-planar folding of the telescopes is used to simultaneously reduce pupil and image plane astigmatism. The former improves the adaptive optics performance by reducing the root-mean-square (RMS) of the wavefront and the beam wandering due to optical scanning. The latter provides diffraction limited performance over a 3 diopter (D) vergence range. This vergence range allows for the use of any broadband light source(s) in the 450-850 nm wavelength range to simultaneously image any combination of retinal layers. Imaging modalities that could benefit from such a large vergence range are optical coherence tomography (OCT), multi- and hyper-spectral imaging, single-and multi-photon fluorescence. The benefits of the non-planar telescopes in the BAOSO are illustrated by resolving the human foveal photoreceptor mosaic in reflectance using two different superluminescent diodes with 680 and 796 nm peak wavelengths, reaching the eye with a vergence of 0.76 D relative to each other. (C) 2011 Optical Society of America
引用
收藏
页码:1757 / 1768
页数:12
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