Current understanding of osteoarthritis pathogenesis and relevant new approaches

被引:231
作者
Tong, Liping [1 ]
Yu, Huan [1 ,2 ]
Huang, Xingyun [1 ,2 ]
Shen, Jie [3 ]
Xiao, Guozhi [4 ]
Chen, Lin [5 ]
Wang, Huaiyu [6 ]
Xing, Lianping [7 ]
Chen, Di [1 ,2 ]
机构
[1] Chinese Acad Sci, Res Ctr Comp Aided Drug Discovery, Shenzhen Inst Adv Technol, Shenzhen 518005, Peoples R China
[2] Chinese Acad Sci, Fac Pharmaceut Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
[3] Washington Univ, Sch Med, Dept Orthoped Surg, St Louis, MO 63110 USA
[4] Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
[5] Army Med Univ, Daping Hosp, Dept Wound Repair & Rehabil, State Key Lab Trauma Burns & Combined Injury, Chongqing 400042, Peoples R China
[6] Chinese Acad Sci, Res Ctr Human Tissues & Organs Degenerat, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
[7] Univ Rochester, Ctr Musculoskeletal Res, Dept Pathol & Lab Med, Med Ctr, Rochester, NY 14642 USA
基金
中国国家自然科学基金;
关键词
NERVE GROWTH-FACTOR; PROGRAMMED CELL-DEATH; NITRIC-OXIDE SYNTHASE; LYMPHATIC SMOOTH-MUSCLE; GENE-RELATED PEPTIDE; HISTONE DEACETYLASE; CPG SITES; ARTICULAR CHONDROCYTES; KNEE OSTEOARTHRITIS; DNA METHYLATION;
D O I
10.1038/s41413-022-00226-9
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA development. To better understand the pathological mechanisms of OA, new approaches, methods, and techniques need to be used to understand OA pathogenesis. In this review, we first focus on the epigenetic regulation of OA, with a particular focus on DNA methylation, histone modification, and microRNA regulation, followed by a summary of several key mediators in OA-associated pain. We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain, such as CRISPR, scRNA sequencing, and lineage tracing. Next, we discuss the timely updates concerning cell death regulation in OA pathology, including pyroptosis, ferroptosis, and autophagy, as well as their individual roles in OA and potential molecular targets in treating OA. Finally, our review highlights new directions on the role of the synovial lymphatic system in OA. An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA.
引用
收藏
页数:17
相关论文
共 258 条
[11]   Circulating MicroRNAs as Biomarkers for Sepsis [J].
Benz, Fabian ;
Roy, Sanchari ;
Trautwein, Christian ;
Roderburg, Christoph ;
Luedde, Tom .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (01)
[12]   Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period [J].
Berenbaum, Francis ;
Blanco, Francisco J. ;
Guermazi, Ali ;
Miki, Kenji ;
Yamabe, Takaharu ;
Viktrup, Lars ;
Junor, Rod ;
Carey, William ;
Brown, Mark T. ;
West, Christine R. ;
Verburg, Kenneth M. .
ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (06) :800-810
[13]  
Bibikova M, 2002, GENETICS, V161, P1169
[14]   Central nervous system monoaminergic activity in hip osteoarthritis patients with disabling pain: associations with pain severity and central sensitization [J].
Bjurstrom, Martin F. ;
Blennow, Kaj ;
Zetterberg, Henrik ;
Bodelsson, Mikael ;
Walden, Markus ;
Dietz, Nicholas ;
Hall, Sara ;
Hansson, Oskar ;
Irwin, Michael R. ;
Mattsson-Carlgren, Niklas .
PAIN REPORTS, 2022, 7 (01) :E988
[15]   Is It Time for Epigenetics in Osteoarthritis? [J].
Blanco, Francisco J. ;
Rego-Perez, Ignacio .
ARTHRITIS & RHEUMATOLOGY, 2014, 66 (09) :2324-2327
[16]   Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis [J].
Bouta, Echoe M. ;
Bell, Richard D. ;
Rahimi, Homaira ;
Xing, Lianping ;
Wood, Ronald W. ;
Bingham, Clifton O., III ;
Ritchlin, Christopher T. ;
Schwarz, Edward M. .
NATURE REVIEWS RHEUMATOLOGY, 2018, 14 (02) :94-106
[17]   HISTONE DEACETYLASES IN BONE DEVELOPMENT AND SKELETAL DISORDERS [J].
Bradley, Elizabeth W. ;
Carpio, Lomeli R. ;
van Wijnen, Andre J. ;
McGee-Lawrence, Meghan E. ;
Westendorf, Jennifer J. .
PHYSIOLOGICAL REVIEWS, 2015, 95 (04) :1359-1381
[18]   Inflammasomes: mechanism of assembly, regulation and signalling [J].
Broz, Petr ;
Dixit, Vishva M. .
NATURE REVIEWS IMMUNOLOGY, 2016, 16 (07) :407-420
[19]  
Buma P, 2000, ANAT RECORD, V260, P51
[20]   Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis [J].
Cai, Dawei ;
Yin, Shasha ;
Yang, Jun ;
Jiang, Qing ;
Cao, Wangsen .
ARTHRITIS RESEARCH & THERAPY, 2015, 17