C?X (X=Br, I) Bond-Tolerant Aerobic Oxidative Cross- Coupling: A Strategy to Selectively Construct ß-Aryl Ketones and Aldehydes

被引：47

作者：

Chen, Mao ^{[1
]}

Wang, Jie ^{[1
]}

Chai, Ziyi ^{[1
]}

You, Cai ^{[1
]}

Lei, Aiwen ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 2-3期

基金：

中国国家自然科学基金;

关键词：

copper; cross-coupling; oxygen; palladium; selectivity; CATALYZED ASYMMETRIC 1,4-ADDITION; SUBSTITUTED ALLYLIC ALCOHOLS; MOLECULAR-OXYGEN; CONJUGATE ADDITION; ARYLBORONIC ACIDS; HECK REACTION; UNSATURATED ALCOHOLS; OXIDASE CATALYSIS; ELECTRON-TRANSFER; ORGANIC HALIDES;

D O I：

10.1002/adsc.201100782

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Using moelcular oxygen as the terminal oxidant, various aryl halide-containing beta-aryl ketones and aldehydes can be synthesized directly from readily available allyic alcohols and boronic acids via palladium-catalyzed oxidative cross-coupling reactions. The dual roles of copper, including electron-carrier and Lewis acid functions, are supposed to be critical for the high reactivity and selectivity of this aerobic oxidative coupling transformation.

引用

页码：341 / 346

页数：6

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