The mechanism of TGF-β signaling during palate development

被引：90

作者：

Iwata, J. ^{[1
]}

Parada, C. ^{[1
]}

Chai, Y. ^{[1
]}

机构：

[1] Univ So Calif, Ostrow Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90033 USA

来源：

ORAL DISEASES | 2011年 / 17卷 / 08期

关键词：

Cranial neural crest cells; TGF-beta signaling mechanism; Cleft palate; CRANIAL NEURAL CREST; MEDIAL-EDGE EPITHELIUM; CELL AUTONOMOUS REQUIREMENT; DIGEORGE-SYNDROME REGION; RESCUES CLEFT-PALATE; I RECEPTOR ALK5; MARFAN-SYNDROME; OROFACIAL CLEFTS; EXTRACELLULAR-MATRIX; SECONDARY PALATE;

D O I：

10.1111/j.1601-0825.2011.01806.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Cleft palate, a malformation of the secondary palate development, is one of the most common human congenital birth defects. Palate formation is a complex process resulting in the separation of the oral and nasal cavities that involves multiple events, including palatal growth, elevation, and fusion. Recent findings show that transforming growth factor beta (TGF-beta) signaling plays crucial roles in regulating palate development in both the palatal epithelium and mesenchyme. Here, we highlight recent advances in our understanding of TGF-beta signaling during palate development. Oral Diseases (2011) 17, 733-744

引用

页码：733 / 744

页数：12

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