An efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system via SmI2-induced reductive intramolecular cyclization

被引：103

作者：

Hori, N ^{[1
]}

Matsukura, H ^{[1
]}

Matsuo, G ^{[1
]}

Nakata, T ^{[1
]}

机构：

[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 14期

关键词：

samarium diiodide; radical reaction; cyclization; tetrahydropyrans;

D O I：

10.1016/S0040-4039(99)00301-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system was developed. The new iterative method involves SmI2-induced reductive intramolecular cyclization of an aldehyde and a beta-alkoxy acrylate as the key step, producing a 2,3-trans-tetrahydropyran ring. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2811 / 2814

页数：4

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