Stem cells in the umbilical cord

被引:296
作者
Weiss, Mark L. [1 ]
Troyer, Deryl L.
机构
[1] Kansas State Univ, Dept Anat & Physiol, Coll Vet Med, Manhattan, KS 66506 USA
来源
STEM CELL REVIEWS | 2006年 / 2卷 / 02期
基金
美国国家卫生研究院;
关键词
umbilical cord matrix cells; Wharton's Jelly; mesenchymal stem cells; umbilical cord blood cells;
D O I
10.1007/s12015-006-0022-y
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Stem cells are the next frontier in medicine. Stem cells are thought to have great therapeutic and biotechnological potential. This will not only to replace damaged or dysfunctional cells, but also rescue them and/or deliver therapeutic proteins after they have been engineered to do so. Currently, ethical and scientific issues surround both embryonic and fetal stem cells and hinder their widespread implementation. In contrast, stem cells recovered postnatally from the umbilical cord, including the umbilical cord blood cells, amnion/placenta, umbilical cord vein, or umbilical cord matrix cells, are a readily available and inexpensive source of cells that are capable of forming many different cell types (i.e., they are "multipotent"). This review will focus on the umbilical cord-derived stem cells and compare those cells with adult bone marrow-derived mesenchymal stem cells.
引用
收藏
页码:155 / 162
页数:8
相关论文
共 78 条
  • [71] Adult stem cells: assessing the case for pluripotency
    Verfaillie, CM
    [J]. TRENDS IN CELL BIOLOGY, 2002, 12 (11) : 502 - 508
  • [72] Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord
    Wang, HS
    Hung, SC
    Peng, ST
    Huang, CC
    Wei, HM
    Guo, YJ
    Fu, YS
    Lai, MC
    Chen, CC
    [J]. STEM CELLS, 2004, 22 (07) : 1330 - 1337
  • [73] Human umbilical cord matrix stem cells: Preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease
    Weiss, Mark L.
    Medicetty, Satish
    Bledsoe, Amber R.
    Rachakatla, Raja Shekar
    Choi, Michael
    Merchav, Shosh
    Luo, Yongquan
    Rao, Mahendra S.
    Velagaleti, Gopalrao
    Troyer, Deryl
    [J]. STEM CELLS, 2006, 24 (03) : 781 - 792
  • [74] Transplantation of porcine umbilical cord matrix cells into the rat brain
    Weiss, ML
    Mitchell, KE
    Hix, JE
    Medicetty, S
    El-Zarkouny, SZ
    Grieger, D
    Troyer, DL
    [J]. EXPERIMENTAL NEUROLOGY, 2003, 182 (02) : 288 - 299
  • [75] A niche maintaining germ line stem cells in the Drosophila ovary
    Xie, T
    Spradling, AC
    [J]. SCIENCE, 2000, 290 (5490) : 328 - 330
  • [76] Clonogenic analysis reveals reserve stem cells in postnatal mammals: I. Pluripotent mesenchymal stem cells
    Young, HE
    Duplaa, C
    Young, TM
    Floyd, JA
    Reeves, ML
    Davis, KH
    Mancini, GJ
    Eaton, ME
    Hill, JD
    Thomas, K
    Austin, T
    Edwards, C
    Cuzzourt, J
    Parikh, A
    Groom, J
    Hudson, J
    Black, AC
    [J]. ANATOMICAL RECORD, 2001, 263 (04): : 350 - 360
  • [77] Human pluripotent and progenitor cells display cell surface cluster differentiation markers CD10, CD13, CD56, and MHC Class-I
    Young, HE
    Steele, TA
    Bray, RA
    Detmer, K
    Blake, LW
    Lucas, PW
    Black, AC
    [J]. PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1999, 221 (01): : 63 - 71
  • [78] Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats
    Zhao, LR
    Duan, WM
    Reyes, M
    Keene, CD
    Verfaillie, CM
    Low, WC
    [J]. EXPERIMENTAL NEUROLOGY, 2002, 174 (01) : 11 - 20