Synthesis and Anticancer Activity of 2-Aryl-3-methylbenzofuro[3,2-b]pyrazolo[4,3-e]azepine-4,11(2H,10H)-dione and 2-Aryl-3,7,9-trimethylpyrido[3',2':4,5]thieno[3,2-b]pyrazolo[4,3-e]azepine-4,11(2H,10H)-diones

被引：12
|
作者：
Chaban, T., I [1 ]
Matiichuk, Y. E. [1 ]
Horishny, V. Ya [1 ]
Chaban, I. G. [1 ]
Matiychuk, V. S. [2 ]
机构：
[1] Danylo Halytsky Lviv Natl Med Univ, UA-79010 Lvov, Ukraine
[2] Ivan Franko Natl Univ Lviv, UA-79005 Lvov, Ukraine
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 05期
关键词：
organic synthesis; heterocyclization; tandem reactions; anticancer activity; ARYLATION PRODUCTS; TANDEM REACTIONS; TRANSFORMATIONS; HETEROCYCLES; DERIVATIVES; DOMINO;
D O I：
10.1134/S1070428020050139
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reactions of ethyl 1-aryl-4-(2-bromoacetyl)-5-methyl-1H-pyrazolocarboxylates withortho-hydroxybenzonitrile and 4,6-dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile gave previously unknown 2-aryl-3-methylbenzofuro[3,2-b]pyrazolo[4,3-e]azepine-4,11(2H,10H)-diones and 2-aryl-3,7,9-trimethylpyrido[3',2':4,5]thieno[3,2-b]pyrazolo[4,3-e]azepine-4,11(2H,10H)-diones, respectively. It was found that this reaction occurred as a tandem process. The synthesized compounds were sceened for anticancer activity and exhibited moderate activity against the most part of malignant cancer cells.
引用
收藏
页码：813 / 818
页数：6
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