Applications of mass spectrometry to signal transduction

被引：10
作者：
Resing, KA
Ahn, NG
机构：
[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
[2] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA
来源：
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 1999年 / 71卷 / 3-4期
关键词：
D O I：
10.1016/S0079-6107(98)00048-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Advances in mass spectrometry instrumentation, protocols for sample handling, and computational methods provide powerful new approaches to solving problems in analytical biochemistry. This review summarizes recent work illustrating ways in which mass spectrometry has been used to address questions relevant to signal transduction. Rather than encompass all of the instruments or methodologies that might be brought to bear on these problems, we present an overview of commonly used techniques, promising new methodologies, and some applications. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：501 / 523
页数：23
相关论文
共 172 条
[1]   Characterization of the structural difference between active and inactive forms of the Ras protein by chemical modification followed by mass spectrometric peptide mapping [J].
Akashi, S ;
Shirouzu, M ;
Terada, T ;
Ito, Y ;
Yokoyama, S ;
Takio, K .
ANALYTICAL BIOCHEMISTRY, 1997, 248 (01) :15-25
[2]  
Amster IJ, 1996, J MASS SPECTROM, V31, P1325
[3]   Phosphopeptide analysis by matrix-assisted laser desorption time-of-flight mass spectrometry [J].
Annan, RS ;
Carr, SA .
ANALYTICAL CHEMISTRY, 1996, 68 (19) :3413-3421
[4]  
[Anonymous], MASS SPECTROMETRY BI
[5]   First steps from a two-dimensional protein index towards a response-regulation map for Bacillus subtilis [J].
Antelmann, H ;
Bernhardt, J ;
Schmid, R ;
Mach, H ;
Volker, U ;
Hecker, M .
ELECTROPHORESIS, 1997, 18 (08) :1451-1463
[6]   Melanie II - a third-generation software package for analysis of two-dimensional electrophoresis images: I. Features and user interface [J].
Appel, RD ;
Palagi, PM ;
Walther, D ;
Vargas, JR ;
Sanchez, JC ;
Ravier, F ;
Pasquali, C ;
Hochstrasser, DF .
ELECTROPHORESIS, 1997, 18 (15) :2724-2734
[7]   Identifying the G protein, G(z alpha), and its associated proteins in nervous tissue using mass spectrometry and microsequencing techniques [J].
Bartlett, SE ;
Hendry, IA .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1997, 15 (03) :267-274
[8]   Mass spectrometry of ribosomes and ribosomal subunits [J].
Benjamin, DR ;
Robinson, CV ;
Hendrick, JP ;
Hartl, FU ;
Dobson, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7391-7395
[9]   Differentiation-related pathways of 1α,25-dihydroxycholecalciferol metabolism in human colon adenocarcinoma-derived Caco-2 cells:: Production of 1α,25-dihydroxy-3epi-cholecalciferol [J].
Bischof, MG ;
Siu-Caldera, ML ;
Weiskopf, A ;
Vouros, P ;
Cross, HS ;
Peterlik, M ;
Reddy, GS .
EXPERIMENTAL CELL RESEARCH, 1998, 241 (01) :194-201
[10]   Osmoresponsive proteins and functional assessment strategies in Saccharomyces cerevisiae [J].
Blomberg, A .
ELECTROPHORESIS, 1997, 18 (08) :1429-1440
12345678910