BCG Infection in Patients With Inborn Errors of Immunity Receiving the Russian BCG Strain

被引：2

作者：

Laberko, Alexandra ^{[1
]}

Yukhacheva, Daria ^{[1
]}

Kan, Nelly ^{[1
]}

Roppelt, Anna ^{[1
]}

Mukhina, Anna ^{[1
]}

Rodina, Yulia ^{[1
]}

Pershin, Dmitry ^{[2
]}

Cheng, Aristine ^{[3
,4
,5
]}

Lionakis, Michail S. ^{[5
]}

Solopova, Galina ^{[6
]}

Kadnikova, Olga ^{[7
]}

Mushkin, Aleksandr ^{[8
]}

Novichkova, Galina ^{[7
]}

Shcherbina, Anna ^{[1
]}

机构：

[1] Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Dept Immunol, 1 Sammy Mashela St, Moscow 117997, Russia

[2] Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Lab Hematopoiet Stem Cell Transplantat & Immunoth, Moscow, Russia

[3] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan

[4] Natl Taiwan Univ, Coll Med, Taipei, Taiwan

[5] NIAID, Lab Clin Immunol & Microbiol, NIH, Bethesda, MD USA

[6] Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Dept Infect Control, Moscow, Russia

[7] Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Moscow, Russia

[8] St Petersburg Res Inst Phthisiopulmonol, Pediat Surg & Orthoped Clin, St Petersburg, Russia

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2022年 / 10卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Inborn errors of immunity; Primary immunodeficiency; Bacillus Calmette-Guierin; BCG infection; BCGitis; BCGosis; BCG strain; Severe combined immunodeficiency; Mendelian susceptibility to mycobacterial disorders; Chronic granulomatous disease; PRIMARY IMMUNODEFICIENCY DISEASES; CHRONIC GRANULOMATOUS-DISEASE; COMPLICATIONS; TUBERCULOSIS; VACCINATION;

D O I：

10.1016/j.jaip.2022.03.032

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BACKGROUND: Bacillus Calmette-Guierin (BCG) vaccination complications are common in inborn errors of immunity (IEI) due to the inability to clear live attenuated Mycobacterium bovis. Various BCG-vaccine strains are used worldwide, and the profile of the Russian BCG strain vaccine complications in IEI is poorly characterized. OBJECTIVE: To evaluate risks of BCG infection in a large cohort of patients with IEI vaccinated with the Russian BCG strain. METHODS: We evaluated 778 patients with IEI vaccinated with the Russian BCG strain. RESULTS: A total of 114 (15%) developed BCG infection, 41 (36%) with local, 19 (17%) with regional, and 54 with (47%) disseminated disease. BCG infection was seen in 58% of the patients with severe combined immunodeficiency (SCID), 82% with chronic granulomatous disease, 50% with innate immune defects, 5% with combined immunodeficiency, and 2% with other IEI. BCG infection presented at a median age of 4 to 5 months in SCID, chronic granulomatous disease, combined immunodeficiency, and other IEI groups versus 12 months in patients with innate immune defects (P < .005). We found no influence of specific genetic defects, CD3(+) and natural killer cell numbers in SCID, or dihydrorhodamine test stimulation index values in chronic granulomatous disease on the BCG-infection risks. All patients with SCID received antimycobacterial therapy at SCID diagnosis even in the absence of active BCG infection. More antimycobacterial agents were required in disseminated relative to local or regional infection (P < .0001). Only 1 of 114 patients (with SCID) died of BCG-related complications (<1%). CONCLUSIONS: BCG infection is common in patients with IEI receiving BCG vaccination. Rational early antimycobacterial therapy, combined with anticytokine agents for posttransplant inflammatory syndrome prevention, and treatment in SCID may prevent BCG-related mortality. (C) 2022 American Academy of Allergy, Asthma & Immunology

引用

页码：1797 / +

页数：15

共 50 条

[31] Diagnostic Challenges in Patients with Inborn Errors of Immunity with Different Manifestations of Immune Dysregulation [J].

Pieniawska-Smiech, Karolina ;

Pasternak, Gerard ;

Lewandowicz-Uszynska, Aleksandra ;

Jutel, Marek .

JOURNAL OF CLINICAL MEDICINE, 2022, 11 (14)

[32] Needs for Increased Awareness of Gastrointestinal Manifestations in Patients With Human Inborn Errors of Immunity [J].

Kim, Eun Sil ;

Kim, Dongsub ;

Yoon, Yoonsun ;

Kwon, Yiyoung ;

Park, Sangwoo ;

Kim, Jihyun ;

Ahn, Kang Mo ;

Ahn, Soomin ;

Choe, Yon Ho ;

Kim, Yae-Jean ;

Kim, Mi Jin .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[33] NF-κB pathway variants in Iranian patients with inborn errors of immunity [J].

Fathi, Nazanin ;

Abolhassani, Hassan ;

Salami, Fereshte ;

Moeini Shad, Tannaz ;

Delavari, Samaneh ;

Yazdani, Reza ;

Kalantari, Arash ;

Ebrahimi, Sareh Sadat ;

Beniafard, Nasrin ;

Mahdaviani, Seyed Alireza ;

Rezaei, Nima .

EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2025, 21 (05) :667-681

[34] Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study [J].

Goudouris, Ekaterini Simoes ;

Pinto-Mariz, Fernanda ;

Mendonca, Leonardo Oliveira ;

Aranda, Carolina Sanchez ;

Guimaraes, Rafaela Rolla ;

Kokron, Cristina ;

Barros, Myrthes Toledo ;

Anisio, Flavia ;

Alonso, Maria Luiza Oliva ;

Marcelino, Fernanda ;

Valle, Solange Oliveira Rodrigues ;

Dortas Junior, Sergio ;

Barreto, Irma Douglas Paes ;

Ferreira, Janaira Fernandes Severo ;

Roxo-Junior, Persio ;

do Rego Silva, Almerinda Maria ;

Campinhos, Fernanda Lugao ;

Bonfim, Carmem ;

Loth, Gisele ;

Fernandes, Juliana Folloni ;

Garcia, Julia Lopes ;

Capelo, Albertina ;

Takano, Olga Akiko ;

Nadaf, Maria Isabel Valdomir ;

Toledo, Eliana C. ;

Cunha, Luciana Araujo Oliveira ;

Di Gesu, Regina Sumiko Watanabe ;

Schidlowski, Laire ;

Fillipo, Priscila ;

Bichuetti-Silva, Danielli C. ;

Soldateli, Gustavo ;

Ferraroni, Natasha Reboucas ;

de Oliveira Dantas, Ellen ;

Pestana, Simone ;

Mansour, Eli ;

Ulaf, Raisa Gusso ;

Prando, Carolina ;

Condino-Neto, Antonio ;

Grumach, Anete Sevciovic .

JOURNAL OF CLINICAL IMMUNOLOGY, 2021, 41 (07) :1479-1489

[35] TREC and KREC profiling as a representative of thymus and bone marrow output in patients with various inborn errors of immunity [J].

Dasouki, M. ;

Jabr, A. ;

AlDakheel, G. ;

Elbadaoui, F. ;

Alazami, A. M. ;

Al-Saud, B. ;

Arnaout, R. ;

Aldhekri, H. ;

Alotaibi, I ;

Al-Mousa, H. ;

Hawwari, A. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2020, 202 (01) :60-71

[36] Immune reconstitution and survival, following hematopoietic stem cell transplantation in Omani patients with inborn errors of immunity [J].

Al-Tamemi, Salem ;

Al-Rawas, Abdulhakim ;

Al-Khabori, Murtadha ;

Al-Farsi, Khalil ;

Al-Huneini, Mohammed ;

Abdalla, Amr ;

Al-Kindi, Salam ;

Dennison, David .

CLINICAL IMMUNOLOGY, 2024, 264

[37] Rheumatologic diseases in patients with inborn errors of immunity in the USIDNET registry [J].

N. Padem ;

H. Wright ;

R. Fuleihan ;

E. Garabedian ;

D. Suez ;

C. Cunningham-Rundles ;

R. A. Marsh ;

A. Khojah .

Clinical Rheumatology, 2022, 41 :2197-2203

[38] Rheumatologic diseases in patients with inborn errors of immunity in the USIDNET registry [J].

Padem, N. ;

Wright, H. ;

Fuleihan, R. ;

Garabedian, E. ;

Suez, D. ;

Cunningham-Rundles, C. ;

Marsh, R. A. ;

Khojah, A. .

CLINICAL RHEUMATOLOGY, 2022, 41 (07) :2197-2203

[39] Vaccination for Patients with Inborn Errors of Immunity: a Nationwide Survey in Japan [J].

Sho Hosaka ;

Takahiro Kido ;

Kazuo Imagawa ;

Hiroko Fukushima ;

Tomohiro Morio ;

Shigeaki Nonoyama ;

Hidetoshi Takada .

Journal of Clinical Immunology, 2022, 42 :183-194

[40] Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity [J].

Tangye, Stuart G. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (04) :818-831

← 1 2 3 4 5 →