Alveolar Epithelial Type II Cells and Their Microenvironment in the Caveolin-1-Deficient Mouse

被引：7
作者：
Jung, Kristina [2 ]
Schlenz, Heike [2 ]
Krasteva, Gabriela [2 ]
Muehlfeld, Christian [1 ,2 ]
机构：
[1] Hannover Med Sch, Inst Funct & Appl Anat, D-30625 Hannover, Germany
[2] Univ Giessen, Inst Anat & Cell Biol, Giessen, Germany
来源：
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2012年 / 295卷 / 02期
关键词：
caveolin-1; caveolae; Type II cells; electron microscopy; stereology; PULMONARY SURFACTANT SYSTEM; LUNG; EXPRESSION; CAVEOLAE; MICE;
D O I：
10.1002/ar.21543
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Caveolin-1 (Cav-1) is highly expressed in alveolar epithelial type I (AE1) and endothelial cells of the alveolar region of the lung. Interestingly, alveolar epithelial type II (AE2) cells that are progenitors of the AE1 cells do not express Cav-1. We investigated whether genetic Cav-1 deficiency alters the phenotype of AE2 cells and their microenvironment using stereology. Total number, mean volume, and subcellular composition of the AE2 cells were not altered in Cav-1-/- when compared with wild-type mice. The alveolar septa were thickened and contained a significantly greater volume of extracellular matrix. Thus, AE2 cells as progenitors of AE1 cells are not critically involved in the severe pulmonary phenotype in Cav-1-deficient mice. Anat Rec, 2012. (C) 2011 Wiley Periodicals, Inc.
引用
收藏
页码：196 / 200
页数：5
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