Altered pre-pulse inhibition in adult rats treated neonatally with domoic acid

被引：20

作者：

Adams, A. L. ^{[2
]}

Doucette, T. A. ^{[2
]}

Ryan, C. L. ^{[1
]}

机构：

[1] Univ Prince Edward Isl, Dept Psychol, Charlottetown, PE C1A 4P3, Canada

[2] Univ Prince Edward Isl, Dept Biol, Charlottetown, PE C1A 4P3, Canada

来源：

AMINO ACIDS | 2008年 / 35卷 / 01期

关键词：

kainate receptors; glutamate; brain development; pre-pulse inhibition; schizophrenia;

D O I：

10.1007/s00726-007-0603-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Altered functioning of the glutamate system during critical periods of development is believed to play a role in various neurodevelopmental disorders, such as schizophrenia. Prepulse inhibition (PPI) of the acoustic startle response is deficient in people with schizophrenia. This study investigated the theory that neonatal treatment with domoic acid (DOM), a glutamate agonist, leads to deficient PPI. Results indicate that neonatal treatment with DOM leads to lowered PPI in adult males and an increased startle response in adult females.

引用

页码：157 / 160

页数：4

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