Construction and validation of m6A RNA methylation regulators associated prognostic model for gastrointestinal cancer

被引：3
作者：
Miao, Yandong [1 ]
Su, Bin [2 ]
Tang, Xiaolong [1 ]
Wang, Jiangtao [1 ]
Quan, Wuxia [3 ]
Chen, Yonggang [4 ]
Mi, Denghai [1 ,5 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 1, 1 Donggang West Rd, Lanzhou 730000, Peoples R China
[2] 920th Hosp Chinese Peoples Liberat Army Joint Log, Dept Oncol, Kunming, Yunnan, Peoples R China
[3] Qingyang Peoples Hosp, Qingyang, Peoples R China
[4] Lanzhou Univ, Hosp 2, 82 Cuiyingmen, Lanzhou 730030, Peoples R China
[5] Gansu Acad Tradit Chinese Med, Lanzhou, Peoples R China
来源：
IET SYSTEMS BIOLOGY | 2022年 / 16卷 / 02期
关键词：
bioinformatic analysis; epigenetics; gastrointestinal carcinoma; m(6)A methylation; RNA modification; PROGRESSION; METABOLISM; EXPRESSION; MECHANISM; GENES;
D O I：
10.1049/syb2.12040
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
N6-methyladenosine (m(6)A) RNA methylation is correlated with carcinogenesis and dynamically possessed through the m(6)A RNA methylation regulators. This paper aimed to explore 13 m(6)A RNA methylation regulators' role in gastrointestinal cancer (GIC) and determine the risk model and prognosis value of m(6)A RNA methylation regulators in GIC. We used several bioinformatics methods to identify the differential expression of m(6)A RNA methylation regulators in GIC, constructed a prognostic model, and carried out functional enrichment analysis. Eleven of 13 m(6)A RNA methylation regulators were differentially expressed in different clinicopathological characteristics of GIC, and m(6)A RNA methylation regulators were nearly associated with GIC. We constructed a risk model based on five m(6)A RNA methylation regulators (METTL3, FTO, YTHDF1, ZC3H13, and WTAP); the risk score is an independent prognosis biomarker. Moreover, the five m(6)A RNA methylation regulators can also forecast the 1-, 3- and 5-year overall survival through a nomogram. Furthermore, four hallmarks of oxidative phosphorylation, glycolysis, fatty acid metabolism, and cholesterol homoeostasis gene sets were significantly enriched in GIC. m(6)A RNA methylation regulators were related to the malignant clinicopathological characteristics of GIC and may be used for prognostic stratification and development of therapeutic strategies.
引用
收藏
页码：59 / 71
页数：13
相关论文
共 53 条
[1]   Cancer risk by combined levels of YKL-40 and C-reactive protein in the general population [J].
Allin, K. H. ;
Bojesen, S. E. ;
Johansen, J. S. ;
Nordestgaard, B. G. .
BRITISH JOURNAL OF CANCER, 2012, 106 (01) :199-205
[2]   From Krebs to clinic: glutamine metabolism to cancer therapy [J].
Altman, Brian J. ;
Stine, Zachary E. ;
Dang, Chi V. .
NATURE REVIEWS CANCER, 2016, 16 (10) :619-634
[3]   YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma [J].
Bai, Yang ;
Yang, Chunxing ;
Wu, Runliu ;
Huang, Lihua ;
Song, Shenlei ;
Li, Wanwan ;
Yan, Peichen ;
Lin, Changwei ;
Li, Daojiang ;
Zhang, Yi .
FRONTIERS IN ONCOLOGY, 2019, 9
[4]   m6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas [J].
Chai, Rui-Chao ;
Wu, Fan ;
Wang, Qi-Xue ;
Zhang, Shu ;
Zhang, Ke-Nan ;
Liu, Yu-Qing ;
Zhao, Zheng ;
Jiang, Tao ;
Wang, Yong-Zhi ;
Kang, Chun-Sheng .
AGING-US, 2019, 11 (04) :1204-1225
[5]   The role of m6A RNA methylation in human cancer [J].
Chen, Xiao-Yu ;
Zhang, Jing ;
Zhu, Jin-Shui .
MOLECULAR CANCER, 2019, 18 (1)
[6]   mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis [J].
Choe, Junho ;
Lin, Shuibin ;
Zhang, Wencai ;
Liu, Qi ;
Wang, Longfei ;
Ramirez-Moya, Julia ;
Du, Peng ;
Kim, Wantae ;
Tang, Shaojun ;
Sliz, Piotr ;
Santisteban, Pilar ;
George, Rani E. ;
Richards, William G. ;
Wong, Kwok-Kin ;
Locker, Nicolas ;
Slack, Frank J. ;
Gregory, Richard I. .
NATURE, 2018, 561 (7724) :556-+
[7]   Cellular Fatty Acid Metabolism and Cancer [J].
Currie, Erin ;
Schulze, Almut ;
Zechner, Rudolf ;
Walther, Tobias C. ;
Farese, Robert V., Jr. .
CELL METABOLISM, 2013, 18 (02) :153-161
[8]   2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members [J].
Daffis, Stephane ;
Szretter, Kristy J. ;
Schriewer, Jill ;
Li, Jianqing ;
Youn, Soonjeon ;
Errett, John ;
Lin, Tsai-Yu ;
Schneller, Stewart ;
Zust, Roland ;
Dong, Hongping ;
Thiel, Volker ;
Sen, Ganes C. ;
Fensterl, Volker ;
Klimstra, William B. ;
Pierson, Theodore C. ;
Buller, R. Mark ;
Gale, Michael, Jr. ;
Shi, Pei-Yong ;
Diamond, Michael S. .
NATURE, 2010, 468 (7322) :452-456
[9]   Cancer Epigenetics: From Mechanism to Therapy [J].
Dawson, Mark A. ;
Kouzarides, Tony .
CELL, 2012, 150 (01) :12-27
[10]   SnapShot: Unconventional miRNA functions [J].
Dragomir, Mihnea Paul ;
Knutsen, Erik ;
Calin, George Adrian .
CELL, 2018, 174 (04) :1038-+
123456