The particles of the embryonic cerebrospinal fluid: How could they influence brain development?

被引：41

作者：

Bachy, Isabelle ^{[1
]}

Kozyraki, Renata ^{[2
]}

Wassef, Marion ^{[1
]}

机构：

[1] Ecole Normale Super, CNRS, UMR 8542, F-75005 Paris, France

[2] Hop St Antoine, INSERM, UMR538, F-75012 Paris, France

来源：

BRAIN RESEARCH BULLETIN | 2008年 / 75卷 / 2-4期

关键词：

cerebrospinal fluid; brain; development; morphogens; growth factors; particles;

D O I：

10.1016/j.brainresbull.2007.10.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During brain development, the embryonic cerebrospinal fluid (E-CSF) allows brain expansion and promotes neuroepithelial cell survival, proliferation or differentiation. Previous analyses of E-CSF content have revealed a high protein concentration and the presence of membranous particles. The role of these particles in the E-CSF remains poorly investigated. In this study we showed that the E-CSF contains at least two pools of particles: lipoproteins and exosome-like particles. We showed that these two populations of particles strongly interact with neuropithelial cells via an endocytic process, which display regional specificity along the developing neural tube. Finally, we explore and discuss the possibility that these interactions may influence brain development through the regulation of morphogen and growth factor signaling transduction. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：289 / 294

页数：6

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